| EC |
6.3.3.7 |
| Accepted name: |
Ni-sirohydrochlorin a,c-diamide reductive cyclase |
| Reaction: |
ATP + Ni-sirohydrochlorin a,c-diamide + 3 reduced electron acceptor + H2O = ADP + phosphate + 15,173-seco-F430-173-acid + 3 electron acceptor |
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| Other name(s): |
cfbC (gene name); cfbD (gene name) |
| Systematic name: |
Ni-sirohydrochlorin a,c-diamide reductive cyclo-ligase (ADP-forming) |
| Comments: |
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Pfaltz, A., Kobelt, A., Huster, R. and Thauer, R.K. Biosynthesis of coenzyme F430 in methanogenic bacteria. Identification of 15,173-seco-F430-173-acid as an intermediate. Eur. J. Biochem. 170 (1987) 459–467. [PMID: 3691535] |
| 2. |
Zheng, K., Ngo, P.D., Owens, V.L., Yang, X.P. and Mansoorabadi, S.O. The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea. Science 354 (2016) 339–342. [DOI] [PMID: 27846569] |
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| [EC 6.3.3.7 created 2017] |
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