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Your query returned 1 entry. Printable version
EC | 6.3.4.2 | ||||||||||||
Accepted name: | CTP synthase (glutamine hydrolysing) | ||||||||||||
Reaction: | ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate (overall reaction) (1a) L-glutamine + H2O = L-glutamate + NH3 (1b) ATP + UTP + NH3 = ADP + phosphate + CTP |
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Other name(s): | UTP—ammonia ligase; cytidine triphosphate synthetase; uridine triphosphate aminase; cytidine 5′-triphosphate synthetase; CTPS (gene name); pyrG (gene name); CTP synthase; UTP:ammonia ligase (ADP-forming) | ||||||||||||
Systematic name: | UTP:L-glutamine amido-ligase (ADP-forming) | ||||||||||||
Comments: | The enzyme contains three functionally distinct sites: an allosteric GTP-binding site, a glutaminase site where glutamine hydrolysis occurs (cf. EC 3.5.1.2, glutaminase), and the active site where CTP synthesis takes place. The reaction proceeds via phosphorylation of UTP by ATP to give an activated intermediate 4-phosphoryl UTP and ADP [4,5]. Ammonia then reacts with this intermediate generating CTP and a phosphate. The enzyme can also use ammonia from the surrounding solution [3,6]. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9023-56-7 | ||||||||||||
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