| EC |
6.3.4.23 |
| Accepted name: |
formate—phosphoribosylaminoimidazolecarboxamide ligase |
| Reaction: |
ATP + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = ADP + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide |
| Other name(s): |
5-formaminoimidazole-4-carboxamide ribonucleotide synthetase; 5-formaminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5′-monophosphate synthetase; purP (gene name) |
| Systematic name: |
formate:5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide ligase (ADP-forming) |
| Comments: |
This archaeal enzyme, characterized from the methanogen Methanocaldococcus jannaschii, catalyses a step in the synthesis of purine nucleotides. It differs from the orthologous bacterial/eukaryotic enzymes, which utilize 10-formyltetrahydrofolate rather than formate and ATP. cf. EC 2.1.2.3, phosphoribosylaminoimidazolecarboxamide formyltransferase. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9032-03-5 |
| References: |
| 1. |
Ownby, K., Xu, H. and White, R.H. A Methanocaldococcus jannaschii archaeal signature gene encodes for a 5-formaminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5′-monophosphate synthetase. A new enzyme in purine biosynthesis. J. Biol. Chem. 280 (2005) 10881–10887. [DOI] [PMID: 15623504] |
| 2. |
Zhang, Y., White, R.H. and Ealick, S.E. Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry 47 (2008) 205–217. [DOI] [PMID: 18069798] |
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| [EC 6.3.4.23 created 2013] |
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