| EC |
6.3.4.3 |
| Accepted name: |
formate—tetrahydrofolate ligase |
| Reaction: |
ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate |
|
For diagram of folate cofactors, click here and for diagram of C1 metabolism, click here |
| Other name(s): |
formyltetrahydrofolate synthetase; 10-formyltetrahydrofolate synthetase; tetrahydrofolic formylase; tetrahydrofolate formylase |
| Systematic name: |
formate:tetrahydrofolate ligase (ADP-forming) |
| Comments: |
In eukaryotes occurs as a trifunctional enzyme also having methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) and methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) activity. |
| Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9023-66-9 |
| References: |
| 1. |
Jaenicke, L. and Brode, E. Untersuchungen über Einkohlenstoffkörper. I. Die Tetrahydrofolatformylase aus Taubenleber. Rinigung und Mechanismus. Biochem. Z. 334 (1961) 108–132. [PMID: 13789141] |
| 2. |
Long, C.W., Levitzki, A., Houston, L.L and Koshland, D.E., Jr. Subunit structures and interactions of CTP synthetase. Fed. Proc. 28 (1969) 342. |
| 3. |
Rabinowitz, J.C. and Pricer, W.E. Formyltetrahydrofolate synthetase. I. Isolation and crystallization of the enzyme. J. Biol. Chem. 237 (1962) 2898–2902. [PMID: 14489619] |
| 4. |
Whiteley, H.R., Osborn, M.J. and Huennekens, F.M. Purification and properties of the formate-activating enzyme from Micrococcus aerogenes. J. Biol. Chem. 234 (1959) 1538–1543. [PMID: 13654413] |
|
| [EC 6.3.4.3 created 1961] |
| |
|
| |
|
Printable version