| EC |
6.3.4.4 |
| Accepted name: |
adenylosuccinate synthase |
| Reaction: |
GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP |
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For diagram of AMP and GMP biosynthesis, click here |
| Other name(s): |
IMP—aspartate ligase; adenylosuccinate synthetase; succinoadenylic kinosynthetase; succino-AMP synthetase |
| Systematic name: |
IMP:L-aspartate ligase (GDP-forming) |
| Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9023-57-8 |
| References: |
| 1. |
Davey, C.L. Synthesis of adenylosuccinic acid in preparations of mammalian skeletal muscle. Nature 183 (1959) 995–996. [PMID: 13644270] |
| 2. |
Lieberman, I. Enzymatic synthesis of adenosine-5′-phosphate from inosine-5′-phosphate. J. Biol. Chem. 223 (1956) 327–339. [PMID: 13376602] |
| 3. |
Yefimochkina, E.F. and Braunstein, A.E. The amination of inosinic acid to adenylic acid in muscle extracts. Arch. Biochem. Biophys. 83 (1959) 350–352. [DOI] [PMID: 13662023] |
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| [EC 6.3.4.4 created 1961] |
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