| EC |
6.3.5.10 |
| Accepted name: |
adenosylcobyric acid synthase (glutamine-hydrolysing) |
| Reaction: |
4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate |
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For diagram of corrin biosynthesis (part 5), click here |
| Other name(s): |
CobQ; cobyric acid synthase; 5′-deoxy-5′-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase; Ado-cobyric acid synthase [glutamine hydrolyzing] |
| Systematic name: |
adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming) |
| Comments: |
Requires Mg2+. NH3 can act instead of glutamine. This enzyme catalyses the four-step amidation sequence from cobyrinic acid a,c-diamide to cobyric acid via the formation of cobyrinic acid triamide, tetraamide and pentaamide intermediates. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 137672-90-3 |
| References: |
| 1. |
Blanche, F., Couder, M., Debussche, L., Thibaut, D., Cameron, B. and Crouzet, J. Biosynthesis of vitamin B12: stepwise amidation of carboxyl groups b, d, e, and g of cobyrinic acid a,c-diamide is catalyzed by one enzyme in Pseudomonas denitrificans. J. Bacteriol. 173 (1991) 6046–6051. [DOI] [PMID: 1917839] |
| 2. |
Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. The biosynthesis of adenosylcobalamin (vitamin B12). Nat. Prod. Rep. 19 (2002) 390–412. [PMID: 12195810] |
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| [EC 6.3.5.10 created 2004] |
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