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Your query returned 1 entry. Printable version
EC | 6.3.5.2 | ||||||||
Accepted name: | GMP synthase (glutamine-hydrolysing) | ||||||||
Reaction: | ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate (overall reaction) (1a) L-glutamine + H2O = L-glutamate + NH3 (1b) ATP + XMP + NH3 = AMP + diphosphate + GMP |
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For diagram of AMP and GMP biosynthesis, click here | |||||||||
Glossary: | XMP = xanthosine 5′-phosphate | ||||||||
Other name(s): | GMP synthetase (glutamine-hydrolysing); guanylate synthetase (glutamine-hydrolyzing); guanosine monophosphate synthetase (glutamine-hydrolyzing); xanthosine 5′-phosphate amidotransferase; guanosine 5′-monophosphate synthetase | ||||||||
Systematic name: | xanthosine-5′-phosphate:L-glutamine amido-ligase (AMP-forming) | ||||||||
Comments: | Involved in the de novo biosynthesis of guanosine nucleotides. An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain. The enzyme can catalyse the second reaction alone in the presence of ammonia. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37318-71-1 | ||||||||
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