| EC |
6.4.1.1 |
| Accepted name: |
pyruvate carboxylase |
| Reaction: |
ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate |
| Other name(s): |
pyruvic carboxylase |
| Systematic name: |
pyruvate:carbon-dioxide ligase (ADP-forming) |
| Comments: |
A biotinyl-protein containing manganese (animal tissues) or zinc (yeast). The animal enzyme requires acetyl-CoA. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9014-19-1 |
| References: |
| 1. |
McClure, W.R., Lardy, H.A. and Kneifel, H.P. Rat liver pyruvate carboxylase. I. Preparation, properties, and cation specificity. J. Biol. Chem. 246 (1971) 3569–3578. [PMID: 5578910] |
| 2. |
Scrutton, M.C., Young, M.R. and Utter, M.F. Pyruvate carboxylase from baker's yeast. The presence of bound zinc. J. Biol. Chem. 245 (1970) 6220–6227. [PMID: 5484476] |
| 3. |
Seubert, W. and Remberger, U. Renigung und Wirkungsweise der Pyruvatcarboxylase aus Pseudomonas citronellolis. Biochem. Z. 334 (1961) 401–414. [PMID: 13750403] |
| 4. |
Utter, M.F. and Keech, D.B. Pyruvate carboxylase. I. Nature of the reaction. J. Biol. Chem. 238 (1963) 2603–2608. [PMID: 14063279] |
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| [EC 6.4.1.1 created 1961] |
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