| EC |
6.7.1.1 |
| Accepted name: |
3-amino-2-hydroxy-4-methoxybenzoate diazotase |
| Reaction: |
ATP + 3-amino-2-hydroxy-4-methoxybenzoate + nitrite = AMP + diphosphate + cremeomycin + H2O |
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For diagram of cremeomycin biosynthesis, click here |
| Glossary: |
cremeomycin = 6-carboxy-2-diazonio-3-methoxyphenolate |
| Other name(s): |
creM (gene name) |
| Systematic name: |
3-amino-2-hydroxy-4-methoxybenzoate:nitrite ligase (AMP-forming) |
| Comments: |
The enzyme, characterized from Streptomyces cremeus, catalyses the last step in the biosynthesis of the ortho-diazoquinone cremeomycin. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Waldman, A.J. and Balskus, E.P. Discovery of a diazo-forming enzyme in cremeomycin biosynthesis. J. Org. Chem. 83 (2018) 7539–7546. [DOI] [PMID: 29771512] |
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| [EC 6.7.1.1 created 2021] |
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