The Enzyme Database

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Accepted name: ferredoxin—NAD+ oxidoreductase (H+-transporting)
Reaction: 2 reduced ferredoxin [iron-sulfur] cluster + NAD+ + H+ + 2 H+[side 1] = 2 oxidized ferredoxin [iron-sulfur] cluster + NADH + 2 H+[side 2]
Other name(s): Rnf complex (ambiguous); H+-translocating ferredoxin:NAD+ oxidoreductase
Systematic name: ferredoxin:NAD+ oxidoreductase (H+-transporting)
Comments: This iron-sulfur and flavin-containing electron transport complex, isolated from some anaerobic bacteria, couples the energy from reduction of NAD+ by ferredoxin to pumping protons out of the cell, generating a proton motive force across the cytoplasmic membrane. Most similar complexes pump sodium ions rather than protons [cf. EC, ferredoxin—NAD+ oxidoreductase (Na+-transporting)].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Tremblay, P.L., Zhang, T., Dar, S.A., Leang, C. and Lovley, D.R. The Rnf complex of Clostridium ljungdahlii is a proton-translocating ferredoxin:NAD+ oxidoreductase essential for autotrophic growth. mBio 4 (2012) e00406. [DOI] [PMID: 23269825]
2.  Wang, L., Bradstock, P., Li, C., McInerney, M.J. and Krumholz, L.R. The role of Rnf in ion gradient formation in Desulfovibrio alaskensis. PeerJ 4:e1919 (2016). [DOI] [PMID: 27114876]
[EC created 2021]

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