ExplorEnz: EC 7.1.1.4

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7.1.1.4

Accepted name:

caldariellaquinol oxidase (H⁺-transporting)

Reaction:

2 caldariellaquinol + O₂ + n H⁺_{[side 1]} = 2 caldariellaquinone + 2 H₂O + n H⁺_{[side 2]}

Glossary:

caldariellaquinol = 6-(3,7,11,15,19,23-hexamethyltetracosyl)-5-(methylsulfanyl)-1-benzothiophene-4,7-diol

Other name(s):

SoxABCD quinol oxidase; SoxABCD complex; quinol oxidase SoxABCD; SoxM supercomplex; aa₃-type quinol oxidase; aa₃ quinol oxidase; cytochrome aa₃; terminal quinol oxidase; terminal quinol:oxygen oxidoreductase; caldariella quinol:dioxygen oxidoreductase; cytochrome aa₃-type oxidase; caldariellaquinol:O₂ oxidoreductase (H⁺-transporting)

Systematic name:

caldariellaquinol:oxygen oxidoreductase (H⁺-transporting)

Comments:

A copper-containing cytochrome. The enzyme from thermophilic archaea is part of the terminal oxidase and catalyses the reduction of O₂ to water, accompanied by the extrusion of protons across the cytoplasmic membrane.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Gleissner, M., Kaiser, U., Antonopoulos, E. and Schafer, G. The archaeal SoxABCD complex is a proton pump in Sulfolobus acidocaldarius. J. Biol. Chem. 272 (1997) 8417–8426. [DOI] [PMID: 9079667]
2.	Purschke, W.G., Schmidt, C.L., Petersen, A. and Schafer, G. The terminal quinol oxidase of the hyperthermophilic archaeon Acidianus ambivalens exhibits a novel subunit structure and gene organization. J. Bacteriol. 179 (1997) 1344–1353. [DOI] [PMID: 9023221]
3.	Gilderson, G., Aagaard, A., Gomes, C.M., Adelroth, P., Teixeira, M. and Brzezinski, P. Kinetics of electron and proton transfer during O₂ reduction in cytochrome aa₃ from A. ambivalens: an enzyme lacking Glu(I-286). Biochim. Biophys. Acta 1503 (2001) 261–270. [DOI] [PMID: 11115638]
4.	Komorowski, L., Verheyen, W. and Schafer, G. The archaeal respiratory supercomplex SoxM from S. acidocaldarius combines features of quinole and cytochrome c oxidases. Biol. Chem. 383 (2002) 1791–1799. [DOI] [PMID: 12530544]
5.	Muller, F.H., Bandeiras, T.M., Urich, T., Teixeira, M., Gomes, C.M. and Kletzin, A. Coupling of the pathway of sulphur oxidation to dioxygen reduction: characterization of a novel membrane-bound thiosulphate:quinone oxidoreductase. Mol. Microbiol. 53 (2004) 1147–1160. [DOI] [PMID: 15306018]
6.	Bandeiras, T.M., Pereira, M.M., Teixeira, M., Moenne-Loccoz, P. and Blackburn, N.J. Structure and coordination of CuB in the Acidianus ambivalens aa₃ quinol oxidase heme-copper center. J. Biol. Inorg. Chem. 10 (2005) 625–635. [DOI] [PMID: 16163550]

[EC 7.1.1.4 created 2013 as EC 1.10.3.13, transferred 2018 to EC 7.1.1.4]