EC |
7.1.2.1 |
Accepted name: |
P-type H+-exporting transporter |
Reaction: |
ATP + H2O + H+[side 1] = ADP + phosphate + H+[side 2] |
Other name(s): |
proton-translocating ATPase; yeast plasma membrane H+-ATPase; yeast plasma membrane ATPase; ATP phosphohydrolase (ambiguous); proton-exporting ATPase; proton transport ATPase; proton-translocating P-type ATPase; H+-transporting ATPase |
Systematic name: |
ATP phosphohydrolase (P-type, H+-exporting) |
Comments: |
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme occurs in protozoa, fungi and plants, and generates an electrochemical potential gradient of protons across the plasma membrane. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Goffeau, A. and Slayman, C. The proton-translocating ATPase of the fungal plasma membrane. Biochim. Biophys. Acta 639 (1981) 197–223. [PMID: 6461354] |
2. |
Serrano, R., Kielland-Brandt, M.C. and Fink, G.R. Yeast plasma membrane ATPase is essential for growth and has homology with (Na++K+)-, K+-and Ca2+-ATPases. Nature 319 (1986) 689–693. [DOI] [PMID: 3005867] |
3. |
Serrano, R. and Portillo, F. Catalytic and regulatory sites of yeast plasma membrane H+-ATPase studied by directed mutagenesis. Biochim. Biophys. Acta 1018 (1990) 195–199. [DOI] [PMID: 2144186] |
4. |
Perlin, D.S., San Francisco, M.J., Slayman, C.W. and Rosen, B.P. H+/ATP stoichiometry of proton pumps from Neurospora crassa and Escherichia coli. Arch. Biochem. Biophys. 248 (1986) 53–61. [PMID: 2425739] |
|
[EC 7.1.2.1 created 1984 as EC 3.6.1.35, transferred 2000 to EC 3.6.3.6, transferred 2018 to EC 7.1.2.1] |
|
|
|
|