| EC |
7.2.1.2 |
| Accepted name: |
ferredoxin—NAD+ oxidoreductase (Na+-transporting) |
| Reaction: |
2 reduced ferredoxin [iron-sulfur] cluster + NAD+ + H+ + Na+[side 1] = 2 oxidized ferredoxin [iron-sulfur] cluster + NADH + Na+[side 2] |
| Other name(s): |
Rnf complex (ambiguous); Na+-translocating ferredoxin:NAD+ oxidoreductase |
| Systematic name: |
ferredoxin:NAD+ oxidoreductase (Na+-transporting) |
| Comments: |
This iron-sulfur and flavin-containing electron transport complex, isolated from the bacterium Acetobacterium woodii, couples the energy from reduction of NAD+ by ferredoxin to pumping sodium ions out of the cell, generating a gradient across the cytoplasmic membrane. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Biegel, E., Schmidt, S. and Muller, V. Genetic, immunological and biochemical evidence for a Rnf complex in the acetogen Acetobacterium woodii. Environ. Microbiol. 11 (2009) 1438–1443. [DOI] [PMID: 19222539] |
| 2. |
Biegel, E. and Muller, V. Bacterial Na+-translocating ferredoxin:NAD+ oxidoreductase. Proc. Natl. Acad. Sci. USA 107 (2010) 18138–18142. [DOI] [PMID: 20921383] |
| 3. |
Hess, V., Schuchmann, K. and Muller, V. The ferredoxin:NAD+ oxidoreductase (Rnf) from the acetogen Acetobacterium woodii requires Na+ and is reversibly coupled to the membrane potential. J. Biol. Chem. 288 (2013) 31496–31502. [DOI] [PMID: 24045950] |
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| [EC 7.2.1.2 created 2015 as EC 1.18.1.8, transferred 2018 to EC 7.2.1.2] |
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