| EC |
7.2.2.1 |
| Accepted name: |
Na+-transporting two-sector ATPase |
| Reaction: |
ATP + H2O + n Na+[side 1] = ADP + phosphate + n Na+[side 2] |
| Other name(s): |
sodium-transporting two-sector ATPase; Na+-translocating ATPase; Na+-translocating FoF1-ATPase; sodium ion specific ATP synthase |
| Systematic name: |
ATP phosphohydrolase (two-sector, Na+-transporting) |
| Comments: |
A multisubunit ATPase transporter found in some halophilic or alkalophilic bacteria that functions in maintaining sodium homeostasis. The enzyme is similar to EC 7.1.2.2 (H+-transporting two-sector ATPase) but pumps Na+ rather than H+. By analogy to EC 7.1.2.2, it is likely that the enzyme pumps 4 sodium ions for every ATP molecule that is hydrolysed. cf. EC 7.2.2.3, P-type Na+ transporter and EC 7.2.2.4, ABC-type Na+ transporter. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Solioz, M. and Davies, K. Operon of vacuolar-type Na+-ATPase of Enterococcus hirae. J. Biol. Chem. 269 (1994) 9453–9459. [PMID: 8144530] |
| 2. |
Takase, K., Kakinuma, S., Yamato, I., Konishi, K., Igarashi, K. and Kanikuma, Y. Sequencing and characterization of the ntp gene cluster for vacuolar-type Na+-translocating ATPase of Enterococcus hirae. J. Biol. Chem. 269 (1994) 11037–11044. [PMID: 8157629] |
| 3. |
Rahlfs, S. and Müller, V. Sequence of subunit c of the Na+-translocating F1Fo-ATPase of Acetobacterium woodii: proposal for determinants of Na+ specificity as revealed by sequence comparisons. FEBS Lett. 404 (1997) 269–271. [DOI] [PMID: 9119076] |
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| [EC 7.2.2.1 created 2000 as EC 3.6.3.15, transferred 2018 to EC 7.2.2.1, modified 2018] |
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