| EC |
7.2.2.11 |
| Accepted name: |
ABC-type Ni2+ transporter |
| Reaction: |
ATP + H2O + Ni2+-[nickel-binding protein][side 1] = ADP + phosphate + Ni2+[side 2] + [nickel-binding protein][side 1] |
| Other name(s): |
nickel ABC transporter; nickel-transporting ATPase; ABC-type nickel-transporter |
| Systematic name: |
ATP phosphohydrolase (ABC-type, Ni2+-importing) |
| Comments: |
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of Ni2+; the identity of the nickel species transported has not been conclusively established. Does not undergo phosphorylation during the transport process. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
| References: |
| 1. |
Kuan, G., Dassa, E., Saurin, N., Hofnung, M. and Saier, M.H., Jr. Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases. Res. Microbiol. 146 (1995) 271–278. [DOI] [PMID: 7569321] |
| 2. |
Hendricks, J.K. and Mobley, H.L. Helicobacter pylori ABC transporter: effect of allelic exchange mutagenesis on urease activity. J. Bacteriol. 179 (1997) 5892–5902. [DOI] [PMID: 9294450] |
| 3. |
Saier, M.H., Jr. Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya. Adv. Microb. Physiol. 40 (1998) 81–136. [PMID: 9889977] |
| 4. |
Griffiths, J.K. and Sansom, C.E. The Transporter Factsbook, Academic Press, San Diego, 1998. |
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| [EC 7.2.2.11 created 2000 as EC 3.6.3.24, transferred 2018 to EC 7.2.2.11] |
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