ExplorEnz: EC 7.2.2.12

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7.2.2.12

Accepted name:

P-type Zn²⁺ transporter

Reaction:

ATP + H₂O + Zn²⁺_{[side 1]} = ADP + phosphate + Zn²⁺_{[side 2]}

Other name(s):

Zn(II)-translocating P-type ATPase; Zn²⁺-exporting ATPase; P1B-type ATPase; HMA4 (gene name); zntA (gene name)

Systematic name:

ATP phosphohydrolase (P-type, Zn²⁺-exporting)

Comments:

A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme, present in prokaryotes and photosynthetic eukaryotes, exports Zn²⁺ and the related cations Cd²⁺ and Pb²⁺.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Beard, S.J., Hashim, R., Membrillo-Hernández, J., Hughes, M.N. and Poole, R.K. Zinc(II) tolerance in Escherichia coli K-12: evidence that the zntA gene (o732) encodes a cation transport ATPase. Mol. Microbiol. 25 (1997) 883–891. [DOI] [PMID: 9364914]
2.	Rensing, C., Mitra, B. and Rosen, B.P. The zntA gene of Escherichia coli encodes a Zn(II)-translocating P-type ATPase. Proc. Natl. Acad. Sci. USA 94 (1997) 14326–14331. [DOI] [PMID: 9405611]
3.	Rensing, C., Sun, Y., Mitra, B. and Rosen, B.P. Pb(II)-translocating P-type ATPases. J. Biol. Chem. 273 (1998) 32614–32617. [DOI] [PMID: 9830000]
4.	Mills, R.F., Francini, A., Ferreira da Rocha, P.S., Baccarini, P.J., Aylett, M., Krijger, G.C. and Williams, L.E. The plant P1B-type ATPase AtHMA4 transports Zn and Cd and plays a role in detoxification of transition metals supplied at elevated levels. FEBS Lett. 579 (2005) 783–791. [DOI] [PMID: 15670847]
5.	Eren, E. and Argüello, J.M. Arabidopsis HMA2, a divalent heavy metal-transporting P(IB)-type ATPase, is involved in cytoplasmic Zn²⁺ homeostasis. Plant Physiol. 136 (2004) 3712–3723. [DOI] [PMID: 15475410]

[EC 7.2.2.12 created 2000 as EC 3.6.3.5, modified 2001, modified 2006, transferred 2018 to EC 7.2.2.12]