The Enzyme Database

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EC 7.2.2.6     
Accepted name: P-type K+ transporter
Reaction: ATP + H2O + K+[side 1] = ADP + phosphate + K+[side 2]
Other name(s): K+-translocating Kdp-ATPase; multi-subunit K+-transport ATPase; K+-transporting ATPase; potassium-importing ATPase; K+-importing ATPase
Systematic name: ATP phosphohydrolase (P-type, K+-importing)
Comments: A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A bacterial enzyme that is involved in K+ import. The probable stoichiometry is one ion per ATP hydrolysed.
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB
References:
1.  Siebers, A. and Altendorf, K. Characterization of the phosphorylated intermediate of the K+-translocating Kdp-ATPase from Escherichia coli. J. Biol. Chem. 264 (1989) 5831–5838. [PMID: 2522440]
2.  Gassel, M., Siebers, A., Epstein, W. and Altendorf, K. Assembly of the Kdp complex, the multi-subunit K+-transport ATPase of Escherichia coli. Biochim. Biophys. Acta 1415 (1998) 77–84. [DOI] [PMID: 9858692]
3.  Huang, C.S., Pedersen, B.P. and Stokes, D.L. Crystal structure of the potassium-importing KdpFABC membrane complex. Nature 546 (2017) 681–685. [DOI] [PMID: 28636601]
[EC 7.2.2.6 created 2000 as EC 3.6.3.12, transferred 2018 to EC 7.2.2.6]
 
 


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