| EC |
7.2.2.9 |
| Accepted name: |
P-type Cu2+ transporter |
| Reaction: |
ATP + H2O + Cu2+[side 1] = ADP + phosphate + Cu2+[side 2] |
| Other name(s): |
Cu2+-exporting ATPase; copB (gene name) |
| Systematic name: |
ATP phosphohydrolase (P-type, Cu2+-exporting) |
| Comments: |
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme from the termophilic archaeon Archaeoglobus fulgidus is involved in copper extrusion from the cell [1,2]. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Mana-Capelli, S., Mandal, A.K. and Arguello, J.M. Archaeoglobus fulgidus CopB is a thermophilic Cu2+-ATPase: functional role of its histidine-rich-N-terminal metal binding domain. J. Biol. Chem. 278 (2003) 40534–40541. [DOI] [PMID: 12876283] |
| 2. |
Jayakanthan, S., Roberts, S.A., Weichsel, A., Arguello, J.M. and McEvoy, M.M. Conformations of the apo-, substrate-bound and phosphate-bound ATP-binding domain of the Cu(II) ATPase CopB illustrate coupling of domain movement to the catalytic cycle. Biosci Rep 32 (2012) 443–453. [DOI] [PMID: 22663904] |
|
| [EC 7.2.2.9 created 2000 as EC 3.6.3.4, modified 2013, transferred 2018 to EC 7.2.2.9] |
| |
|
| |
|
Printable version