ExplorEnz: EC 7.2.3.1

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7.2.3.1

Accepted name:

Na⁺-exporting diphosphatase

Reaction:

diphosphate + H₂O + Na⁺_{[side 1]} = 2 phosphate + Na⁺_{[side 2]}

Other name(s):

Na⁺-translocating membrane pyrophosphatase; sodium-translocating pyrophosphatase

Systematic name:

diphosphate phosphohydrolase (Na⁺-transporting)

Comments:

Requires Na⁺ and K⁺. This enzyme, found in some bacteria and archaea, couples the energy from diphosphate hydrolysis to active sodium translocation across the membrane. The enzyme is electrogenic, as the Na⁺ transport results in generation of a positive potential in the inner side of the membrane.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Belogurov, G.A., Malinen, A.M., Turkina, M.V., Jalonen, U., Rytkonen, K., Baykov, A.A. and Lahti, R. Membrane-bound pyrophosphatase of Thermotoga maritima requires sodium for activity. Biochemistry 44 (2005) 2088–2096. [DOI] [PMID: 15697234]
2.	Malinen, A.M., Belogurov, G.A., Baykov, A.A. and Lahti, R. Na⁺-pyrophosphatase: a novel primary sodium pump. Biochemistry 46 (2007) 8872–8878. [DOI] [PMID: 17605473]
3.	Luoto, H.H., Belogurov, G.A., Baykov, A.A., Lahti, R. and Malinen, A.M. Na⁺-translocating membrane pyrophosphatases are widespread in the microbial world and evolutionarily precede H⁺-translocating pyrophosphatases. J. Biol. Chem. 286 (2011) 21633–21642. [DOI] [PMID: 21527638]

[EC 7.2.3.1 created 2021 as EC 7.1.3.2, transferred 2022 to EC 7.2.3.1]