| EC |
7.4.2.10 |
| Accepted name: |
ABC-type glutathione transporter |
| Reaction: |
ATP + H2O + glutathione-[glutathione-binding protein][side 1] = ADP + phosphate + glutathione[side 2] + [glutathione-binding protein][side 1] |
| Other name(s): |
glutathione transporting ATPase; glutathione ABC transporter; gsiACD (gene names) |
| Systematic name: |
ATP phosphohydrolase (ABC-type,glutathione-importing) |
| Comments: |
A prokaryotic ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from the bacterium Escherichia coli is a heterotrimeric complex that interacts with an extracytoplasmic substrate binding protein to mediate the uptake of glutathione. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Suzuki, H., Koyanagi, T., Izuka, S., Onishi, A. and Kumagai, H. The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette. J. Bacteriol. 187 (2005) 5861–5867. [PMID: 16109926] |
| 2. |
Moussatova, A., Kandt, C., O'Mara, M.L. and Tieleman, D.P. ATP-binding cassette transporters in Escherichia coli. Biochim. Biophys. Acta 1778 (2008) 1757–1771. [PMID: 18634750] |
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| [EC 7.4.2.10 created 2019] |
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