ExplorEnz: EC 7.4.2.11

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7.4.2.11

Accepted name:

ABC-type methionine transporter

Reaction:

(1) ATP + H₂O + L-methionine-[methionine-binding protein]_{[side 1]} = ADP + phosphate + L-methionine_{[side 2]} + [methionine-binding protein]_{[side 1]}
(2) ATP + H₂O + D-methionine-[methionine-binding protein]_{[side 1]} = ADP + phosphate + D-methionine_{[side 2]} + [methionine-binding protein]_{[side 1]}

Other name(s):

methionine transporting ATPase; methionine ABC transporter; metNIQ (gene names)

Systematic name:

ATP phosphohydrolase (ABC-type, methionine-importing)

Comments:

ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and functions to import methionine. The enzyme from Escherichia coli K-12 mediates the high affinity transport of both L- and D-methionine, as well as methionine-S-oxide and N-acetyl-DL-methionine.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Merlin, C., Gardiner, G., Durand, S. and Masters, M. The Escherichia coli metD locus encodes an ABC transporter which includes Abc (MetN), YaeE (MetI), and YaeC (MetQ). J. Bacteriol. 184 (2002) 5513–5517. [PMID: 12218041]
2.	Zhang, Z., Feige, J.N., Chang, A.B., Anderson, I.J., Brodianski, V.M., Vitreschak, A.G., Gelfand, M.S. and Saier, M.H., Jr. A transporter of Escherichia coli specific for L- and D-methionine is the prototype for a new family within the ABC superfamily. Arch. Microbiol. 180 (2003) 88–100. [PMID: 12819857]
3.	Moussatova, A., Kandt, C., O'Mara, M.L. and Tieleman, D.P. ATP-binding cassette transporters in Escherichia coli. Biochim. Biophys. Acta 1778 (2008) 1757–1771. [PMID: 18634750]

[EC 7.4.2.11 created 2019]