| EC |
7.6.2.13 |
| Accepted name: |
ABC-type autoinducer-2 transporter |
| Reaction: |
ATP + H2O + (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran-[AI-2-binding protein][side 1] = ADP + phosphate + (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran[side 2] + [AI-2-binding protein][side 1] |
| Glossary: |
autoinducer-2 = AI-2 = (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran |
| Other name(s): |
autoinducer-2 transporting ATPase; autoinducer-2 ABC transporter; LsrACDB (gene names) |
| Systematic name: |
ATP phosphohydrolase (ABC-type, AI-2 importing) |
| Comments: |
ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the uptake of the signalling molecule (2R,4S)-2-methyl-2,3,3,4-tetrahydoxytetrahydrofuran (also known as autoinducer-2). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
| References: |
| 1. |
Taga, M.E., Semmelhack, J.L. and Bassler, B.L. The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. Mol. Microbiol. 42 (2001) 777–793. [PMID: 11722742] |
| 2. |
Xavier, K.B. and Bassler, B.L. Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli. J. Bacteriol. 187 (2005) 238–248. [PMID: 15601708] |
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| [EC 7.6.2.13 created 2019] |
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