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Your query returned 3 entries. Printable version
EC | 1.14.13.106 | ||||
Transferred entry: | epi-isozizaene 5-monooxygenase, now classified as EC 1.14.15.39, epi-isozizaene 5-monooxygenase. | ||||
EC | 1.14.15.39 | ||||
Accepted name: | epi-isozizaene 5-monooxygenase | ||||
Reaction: | (+)-epi-isozizaene + 4 reduced [2Fe-2S] ferredoxin + 4 H+ + 2 O2 = albaflavenone + 4 oxidized [2Fe-2S] ferredoxin + 3 H2O (overall reaction) (1a) (+)-epi-isozizaene + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2 = (5S)-albaflavenol + 2 oxidized [2Fe-2S] ferredoxin + H2O (1b) (5S)-albaflavenol + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2 = albaflavenone + 2 oxidized [2Fe-2S] ferredoxin + 2 H2O (2a) (+)-epi-isozizaene + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2 = (5R)-albaflavenol + 2 oxidized [2Fe-2S] ferredoxin + H2O (2b) (5R)-albaflavenol + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2 = albaflavenone + 2 oxidized [2Fe-2S] ferredoxin + 2 H2O |
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For diagram of reaction, click here | |||||
Glossary: | (+)-epi-isozizaene = (3S,3aR,6S)-3,7,7,8-tetramethyl-2,3,4,5,6,7-hexahydro-1H-3a,6-methanoazulene | ||||
Other name(s): | CYP170A1 | ||||
Systematic name: | (+)-epi-isozizaene,reduced-ferredoxin:oxygen oxidoreductase (5-hydroxylating) | ||||
Comments: | This cytochrome-P-450 enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses two sequential allylic oxidation reactions. The substrate epi-isozizaene, which is formed by the action of EC 4.2.3.37, epi-isozizaene synthase, is first oxidized to yield the epimeric intermediates (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 1207718-51-1 | ||||
References: |
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EC | 4.2.3.37 | ||||
Accepted name: | epi-isozizaene synthase | ||||
Reaction: | (2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate | ||||
Other name(s): | SCO5222 protein | ||||
Systematic name: | (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming] | ||||
Comments: | Requires Mg2+ for activity. The displacement of the diphosphate group of farnesyl diphosphate occurs with retention of configuration [1]. In the soil-dwelling bacterium Streptomyces coelicolor A3(2), the product of this reaction is used by EC 1.14.13.106, epi-isozizaene 5-monooxygenase, to produce the sesquiterpene antibiotic albaflavenone [2]. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
References: |
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