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Your query returned 3 entries. Printable version
EC | 2.3.1.182 | ||||
Transferred entry: | (R)-citramalate synthase. Now classified as EC 2.3.3.21, (R)-citramalate synthase. | ||||
EC | 2.3.3.21 | ||||
Accepted name: | (R)-citramalate synthase | ||||
Reaction: | acetyl-CoA + pyruvate + H2O = CoA + (2R)-2-hydroxy-2-methylbutanedioate | ||||
Glossary: | (2R)-2-hydroxy-2-methylbutanedioate = (2R)-2-methylmalate = (–)-citramalate 3-methyl-2-oxobutanoate = α-ketoisovalerate 2-oxobutanoate = α-ketobutyrate 4-methyl-2-oxopentanoate = α-ketoisocaproate 2-oxohexanoate = α-ketopimelate 2-oxoglutarate = α-ketoglutarate |
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Other name(s): | CimA | ||||
Comments: | One of the enzymes involved in a pyruvate-derived pathway for isoleucine biosynthesis that is found in some bacterial and archaeal species [1,2]. The enzyme can be inhibited by isoleucine, the end-product of the pathway, but not by leucine [2]. The enzyme is highly specific for pyruvate as substrate, as the 2-oxo acids 3-methyl-2-oxobutanoate, 2-oxobutanoate, 4-methyl-2-oxopentanoate, 2-oxohexanoate and 2-oxoglutarate cannot act as substrate [1,2]. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 4.2.1.35 | ||||
Accepted name: | (R)-2-methylmalate dehydratase | ||||
Reaction: | (R)-2-methylmalate = 2-methylmaleate + H2O | ||||
Other name(s): | citraconate hydratase; citraconase; citramalate hydro-lyase; (-)-citramalate hydro-lyase; (R)-2-methylmalate hydro-lyase | ||||
Systematic name: | (R)-2-methylmalate hydro-lyase (2-methylmaleate-forming) | ||||
Comments: | Requires Fe2+. | ||||
Links to other databases: | BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9027-92-3 | ||||
References: |
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