| EC |
4.8.1.1 |
| Accepted name: |
L-piperazate synthase |
| Reaction: |
N5-hydroxy-L-ornithine = (3S)-1,2-diazinane-3-carboxylate + H2O |
| Glossary: |
(3S)-1,2-diazinane-3-carboxylate = (3S)-pyridazin-3-carboxylate = L-piperazate |
| Other name(s): |
ktzT (gene name) |
| Systematic name: |
(3S)-1,2-diazinane-3-carboxylate hydrolase (N5-hydroxy-L-ornithine-forming) |
| Comments: |
Contains a heme b cofactor. The enzyme, characterized from the bacterium Kutzneria sp. 744, is one of very few enzymes known to result in the formation of an N-N bond. (3S)-1,2-diazinane-3-carboxylate (piperazate) is known to be incorporated into assorted secondary products that are produced by nonribosomal peptide synthetase or nonribosomal peptide synthetase/polyketide synthase hybrid pathways, such as the kutznerides, padanamides, himastatins, and sanglifehrins. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Du, Y.L., He, H.Y., Higgins, M.A. and Ryan, K.S. A heme-dependent enzyme forms the nitrogen-nitrogen bond in piperazate. Nat. Chem. Biol. 13 (2017) 836–838. [DOI] [PMID: 28628093] |
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| [EC 4.8.1.1 created 2021] |
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