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Your query returned 4 entries. Printable version
EC | 1.14.13.68 | ||||||||||
Transferred entry: | 4-hydroxyphenylacetaldehyde oxime monooxygenase. Now EC 1.14.14.37, 4-hydroxyphenylacetaldehyde oxime monooxygenase | ||||||||||
EC | 1.14.14.37 | ||||||||||
Accepted name: | 4-hydroxyphenylacetaldehyde oxime monooxygenase | ||||||||||
Reaction: | (E)-4-hydroxyphenylacetaldehyde oxime + [reduced NADPH—hemoprotein reductase] + O2 = (S)-4-hydroxymandelonitrile + [oxidized NADPH—hemoprotein reductase] + 2 H2O (overall reaction) (1a) (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime (1b) (Z)-4-hydroxyphenylacetaldehyde oxime = 4-hydroxyphenylacetonitrile + H2O (1c) 4-hydroxyphenylacetonitrile + [reduced NADPH—hemoprotein reductase] + O2 = (S)-4-hydroxymandelonitrile + [oxidized NADPH—hemoprotein reductase] + H2O |
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For diagram of dhurrin biosynthesis, click here | |||||||||||
Glossary: | (S)-4-hydroxymandelonitrile = (2S)-hydroxy(4-hydroxyphenyl)acetonitrile | ||||||||||
Other name(s): | 4-hydroxybenzeneacetaldehyde oxime monooxygenase; cytochrome P450II-dependent monooxygenase; NADPH-cytochrome P450 reductase (CYP71E1); CYP71E1; 4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase | ||||||||||
Systematic name: | (E)-4-hydroxyphenylacetaldehyde oxime,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase | ||||||||||
Comments: | This cytochrome P-450 (heme thiolate) enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum. It catalyses three different activities - isomerization of the (E) isomer to the (Z) isomer, dehydration, and C-hydroxylation. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||
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EC | 2.4.1.85 | ||||||||||
Accepted name: | cyanohydrin β-glucosyltransferase | ||||||||||
Reaction: | UDP-α-D-glucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxymandelonitrile β-D-glucoside | ||||||||||
For diagram of dhurrin biosynthesis, click here | |||||||||||
Glossary: | dhurrin = (S)-4-hydroxymandelonitrile β-D-glucoside | ||||||||||
Other name(s): | uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase; UDP-glucose-p-hydroxymandelonitrile glucosyltransferase; uridine diphosphoglucose-cyanohydrin glucosyltransferase; uridine diphosphoglucose:aldehyde cyanohydrin β-glucosyltransferase; UDP-glucose:(S)-4-hydroxymandelonitrile β-D-glucosyltransferase; UGT85B1; UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase; UDP-D-glucose:(S)-4-hydroxymandelonitrile β-D-glucosyltransferase | ||||||||||
Systematic name: | UDP-α-D-glucose:(S)-4-hydroxymandelonitrile β-D-glucosyltransferase (configuration-inverting) | ||||||||||
Comments: | Acts on a wide range of substrates in vitro, including cyanohydrins, terpenoids, phenolics, hexanol derivatives and plant hormones, in a regiospecific manner [3]. This enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum, along with EC 1.14.14.36, tyrosine N-monooxygenase and EC 1.14.14.37, 4-hydroxyphenylacetaldehyde oxime monooxygenase. This reaction prevents the disocciation and release of toxic hydrogen cyanide [3]. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 55354-52-4 | ||||||||||
References: |
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EC | 4.1.2.11 | ||||||||||
Accepted name: | hydroxymandelonitrile lyase | ||||||||||
Reaction: | (S)-4-hydroxymandelonitrile = cyanide + 4-hydroxybenzaldehyde | ||||||||||
Other name(s): | hydroxynitrile lyase; oxynitrilase; Sorghum hydroxynitrile lyase; (S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase | ||||||||||
Systematic name: | (S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming) | ||||||||||
Comments: | Does not accept aliphatic hydroxynitriles, unlike EC 4.1.2.10 (mandelonitrile lyase), EC 4.1.2.46 [aliphatic (R)-hydroxynitrile lyase] and EC 4.1.2.47 [(S)-hydroxynitrile ketone-lyase (cyanide forming)]. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9075-38-1 | ||||||||||
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