The Enzyme Database

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Accepted name: cucurbitadienol 11-hydroxylase
Reaction: cucurbitadienol + 2 [reduced NADPH—hemoprotein reductase] + 2 O2 = 11-oxocucurbitadienol + 2 [oxidized NADPH—hemoprotein reductase] + 3 H2O (overall reaction)
(1a) cucurbitadienol + [reduced NADPH—hemoprotein reductase] + O2 = 11-hydroxycucurbitadienol + [oxidized NADPH—hemoprotein reductase] + H2O
(1b) 11-hydroxycucurbitadienol + [reduced NADPH—hemoprotein reductase] + O2 = 11-oxocucurbitadienol + [oxidized NADPH—hemoprotein reductase] + 2 H2O
For diagram of cucurbitadienol metabolites, click here
Glossary: 11-oxocucurbitadienol = 3β-hydroxycucurbita-7,24-dien-11-one
Other name(s): CYP87D18
Systematic name: cucurbitadienol,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (11-oxocucurbitadienol-forming)
Comments: Isolated from the plant Siraitia grosvenorii (monk fruit).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Zhang, J., Dai, L., Yang, J., Liu, C., Men, Y., Zeng, Y., Cai, Y., Zhu, Y. and Sun, Y. Oxidation of cucurbitadienol catalyzed by CYP87D18 in the biosynthesis of mogrosides from Siraitia grosvenorii. Plant Cell Physiol. 57 (2016) 1000–1007. [DOI] [PMID: 26903528]
[EC created 2018]

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