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Your query returned 2 entries. Printable version
EC | 2.4.1.284 | ||||
Accepted name: | 2-deoxystreptamine glucosyltransferase | ||||
Reaction: | UDP-α-D-glucose + 2-deoxystreptamine = UDP + 2′-deamino-2′-hydroxyparomamine | ||||
Glossary: | 2′-deamino-2′-hydroxyparomamine = 4-O-α-D-glucopyranosyl-2-deoxy-D-streptamine | ||||
Other name(s): | kanF (gene name) | ||||
Systematic name: | UDP-α-D-glucose:2-deoxystreptamine 6-α-D-glucosyltransferase | ||||
Comments: | Involved in the biosynthesis of kanamycin B and kanamycin C. Also catalyses EC 2.4.1.283, 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase, but activity is only one fifth of that with UDP-α-D-glucose. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 2.4.1.301 | ||||
Accepted name: | 2′-deamino-2′-hydroxyneamine 1-α-D-kanosaminyltransferase | ||||
Reaction: | (1) UDP-α-D-kanosamine + 2′-deamino-2′-hydroxyneamine = UDP + kanamycin A (2) UDP-α-D-kanosamine + neamine = UDP + kanamycin B (3) UDP-α-D-kanosamine + paromamine = UDP + kanamycin C (4) UDP-α-D-kanosamine + 2′-deamino-2′-hydroxyparomamine = UDP + kanamycin X |
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For diagram of kanamycin A biosynthesis, click here | |||||
Glossary: | neamine = (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside paromamine = (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2-deoxy-α-D-glucopyranoside UDP-α-D-kanosamine = uridine 5′-[3-(3-amino-3-deoxy-α-D-glucopyranosyl) diphosphate] kanamycin A = (1S,2R,3R,4S,6R)-4,6-diamino-3-(6-amino-6-deoxy-α-D-glucopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-α-D-glucopyranoside kanamycin B = (1R,2S,3S,4R,6S)-4,6-diamino-3-(3-amino-3-deoxy-α-D-glucopyranosyloxy)-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside kanamycin C = (1R,2S,3S,4R,6S)-4,6-diamino-3-(3-amino-3-deoxy-α-D-glucopyranosyloxy)-2-hydroxycyclohexyl 2-amino-2-deoxy-α-D-glucopyranoside kanamycin X = (1S,2R,3R,4S,6R)-4,6-diamino-3-(α-D-glucopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-α-D-glucopyranoside |
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Other name(s): | kanE (gene name); kanM2 (gene name) | ||||
Systematic name: | UDP-α-D-kanosamine:2′-deamino-2′-hydroxyneamine 1-α-D-kanosaminyltransferase | ||||
Comments: | Involved in the biosynthetic pathway of kanamycins. The enzyme characterized from the bacterium Streptomyces kanamyceticus can also accept UDP-α-D-glucose with lower efficiency [2]. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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