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Your query returned 2 entries. Printable version
EC | 1.17.4.4 | ||||||||||||||
Accepted name: | vitamin-K-epoxide reductase (warfarin-sensitive) | ||||||||||||||
Reaction: | (1) phylloquinone + a protein with a disulfide bond + H2O = 2,3-epoxyphylloquinone + a protein with reduced L-cysteine residues (2) phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues |
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For diagram of the vitamin K cycle, click here | |||||||||||||||
Glossary: | phylloquinone = vitamin K1 = 2-methyl-3-phytyl-1,4-naphthoquinone 2,3-epoxyphylloquinone = vitamin K1 2,3-epoxide = 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone |
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Other name(s): | VKORC1 (gene name); VKORC1L1 (gene name) | ||||||||||||||
Systematic name: | phylloquinone:disulfide oxidoreductase | ||||||||||||||
Comments: | The enzyme catalyses the reduction of vitamin K 2,3-epoxide, which is formed by the activity of EC 4.1.1.90, peptidyl-glutamate 4-carboxylase, back to its phylloquinol active form. The enzyme forms a tight complex with EC 5.3.4.1, protein disulfide-isomerase, which transfers the required electrons from newly-synthesized proteins by catalysing the formation of disulfide bridges. The enzyme acts on the epoxide forms of both phylloquinone (vitamin K1) and menaquinone (vitamin K2). Inhibited strongly by (S)-warfarin and ferulenol. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 55963-40-1 | ||||||||||||||
References: |
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EC | 1.17.4.5 | ||||||||||||||
Accepted name: | vitamin-K-epoxide reductase (warfarin-insensitive) | ||||||||||||||
Reaction: | 3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol = 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol | ||||||||||||||
Glossary: | 2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone = vitamin K 2,3-epoxide | ||||||||||||||
Systematic name: | 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase | ||||||||||||||
Comments: | Vitamin K 2,3-epoxide is reduced to 3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithiothreitol, which is oxidized to a disulfide. Not inhibited by warfarin [cf. EC 1.17.4.4, vitamin-K-epoxide reductase (warfarin-sensitive)]. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 97089-80-0 | ||||||||||||||
References: |
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