| EC |
1.14.13.149 |
| Accepted name: |
phenylacetyl-CoA 1,2-epoxidase |
| Reaction: |
phenylacetyl-CoA + NADPH + H+ + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP+ + H2O |
|
For diagram of aerobic phenylacetate catabolism, click here |
| Glossary: |
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-{7-oxabicyclo[4.1.0]hepta-2,4-dien-1-yl}acetyl-CoA |
| Other name(s): |
ring 1,2-phenylacetyl-CoA epoxidase; phenylacetyl-CoA monooxygenase; PaaAC; PaaABC(D)E |
| Systematic name: |
phenylacetyl-CoA:oxygen oxidoreductase (1,2-epoxidizing) |
| Comments: |
Part of the aerobic pathway of phenylacetate catabolism in Escherichia coli and Pseudomonas putida. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Teufel, R., Mascaraque, V., Ismail, W., Voss, M., Perera, J., Eisenreich, W., Haehnel, W. and Fuchs, G. Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Proc. Natl. Acad. Sci. USA 107 (2010) 14390–14395. [DOI] [PMID: 20660314] |
| 2. |
Grishin, A.M., Ajamian, E., Zhang, L. and Cygler, M. Crystallization and preliminary X-ray analysis of PaaAC, the main component of the hydroxylase of the Escherichia coli phenylacetyl-coenzyme A oxygenase complex. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (2010) 1045–1049. [DOI] [PMID: 20823522] |
| 3. |
Grishin, A.M., Ajamian, E., Tao, L., Zhang, L., Menard, R. and Cygler, M. Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex. J. Biol. Chem. 286 (2011) 10735–10743. [DOI] [PMID: 21247899] |
|
| [EC 1.14.13.149 created 2012] |
| |
|
| |
|
| EC |
5.3.3.18 |
| Accepted name: |
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase |
| Reaction: |
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-oxepin-2(3H)-ylideneacetyl-CoA |
|
For diagram of aerobic phenylacetate catabolism, click here |
| Glossary: |
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-{7-oxabicyclo[4.1.0]hepta-2,4-dien-1-yl}acetyl-CoA
oxepin-CoA = 2-oxepin-2(3H)-ylideneacetyl-CoA |
| Other name(s): |
paaG (gene name); 1,2-epoxyphenylacetyl-CoA isomerase (misleading) |
| Systematic name: |
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase |
| Comments: |
The enzyme catalyses the reversible isomerization of 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA to the unusual unsaturated, oxygen-containing, seven-member heterocyclic enol ether 2-oxepin-2(3H)-ylideneacetyl-CoA, as part of an aerobic phenylacetate degradation pathway. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Ismail, W., El-Said Mohamed, M., Wanner, B.L., Datsenko, K.A., Eisenreich, W., Rohdich, F., Bacher, A. and Fuchs, G. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Eur. J. Biochem. 270 (2003) 3047–3054. [DOI] [PMID: 12846838] |
| 2. |
Teufel, R., Mascaraque, V., Ismail, W., Voss, M., Perera, J., Eisenreich, W., Haehnel, W. and Fuchs, G. Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Proc. Natl. Acad. Sci. USA 107 (2010) 14390–14395. [DOI] [PMID: 20660314] |
|
| [EC 5.3.3.18 created 2011] |
| |
|
| |
|
Printable version