EC |
1.2.1.78 |
Accepted name: |
2-formylbenzoate dehydrogenase |
Reaction: |
2-formylbenzoate + NAD+ + H2O = o-phthalic acid + NADH + H+ |
Glossary: |
o-phthalic acid = benzene-1,2-dicarboxylic acid
2-formylbenzoate = 2-carboxybenzaldehyde |
Other name(s): |
2-carboxybenzaldehyde dehydrogenase; 2CBAL dehydrogenase; PhdK |
Systematic name: |
2-formylbenzoate:NAD+ oxidoreductase |
Comments: |
The enzyme is involved in phenanthrene degradation. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Iwabuchi, T. and Harayama, S. Biochemical and genetic characterization of 2-carboxybenzaldehyde dehydrogenase, an enzyme involved in phenanthrene degradation by Nocardioides sp. strain KP7. J. Bacteriol. 179 (1997) 6488–6494. [DOI] [PMID: 9335300] |
2. |
Kiyohara, H., Nagao, K. and Yano, K. Isolation and some properties of NAD-linked 2-carboxybenzaldehyde dehydrogenase in Alcaligenes faecalis AFK 2 grown on phenanthrene. J. Gen. Appl. Microbiol. 27 (1981) 443–455. |
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[EC 1.2.1.78 created 2010] |
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EC |
4.1.2.34 |
Accepted name: |
4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase |
Reaction: |
(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O = 2-formylbenzoate + pyruvate |
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For diagram of phenanthrene catabolism, click here |
Other name(s): |
2′-carboxybenzalpyruvate aldolase; (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase; (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-formylbenzoate-lyase |
Systematic name: |
(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-formylbenzoate-lyase (pyruvate-forming) |
Comments: |
Involved, with EC 1.13.11.38 (1-hydroxy-2-naphthoate 1,2-dioxygenase), in the metabolism of phenanthrene in bacteria. |
Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, CAS registry number: 86611-90-7 |
References: |
1. |
Barnsley, E.A. Phthalate pathway of phenanthrene metabolism: formation of 2′-carboxybenzalpyruvate. J. Bacteriol. 154 (1983) 113–117. [PMID: 6833175] |
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[EC 4.1.2.34 created 1989] |
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