EC
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1.14.13.116
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Transferred entry: | geranylhydroquinone 3-hydroxylase. Now EC 1.14.14.174, geranylhydroquinone 3-hydroxylase.
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[EC 1.14.13.116 created 2010, deleted 2020] |
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EC |
1.14.14.174 |
Accepted name: |
geranylhydroquinone 3′′-hydroxylase |
Reaction: |
geranylhydroquinone + [reduced NADPH—hemoprotein reductase] + O2 = 3′′-hydroxygeranylhydroquinone + [oxidized NADPH—hemoprotein reductase] + H2O |
Glossary: |
3′′-hydroxygeranylhydroquinone = 2-[(2Z)-3-(hydroxymethyl)-7-methylocta-2,6-dien-1-yl]benzene-1,4-diol |
Other name(s): |
GHQ 3′′-hydroxylase; CYP76B74 (gene name); geranylhydroquinone,NADPH:oxygen oxidoreductase (3′′-hydroxylating) |
Systematic name: |
geranylhydroquinone,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (3′′-hydroxylating) |
Comments: |
A cytochrome P-450 (heme-thiolate) protein found in plants, where it is part of the biosynthesis pathway of the red naphthoquinone pigment shikonin. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Yamamoto, H., Inoue, K., Li, S.M. and Heide, L. Geranylhydroquinone 3′′-hydroxylase, a cytochrome P-450 monooxygenase from Lithospermum erythrorhizon cell suspension cultures. Planta 210 (2000) 312–317. [DOI] [PMID: 10664138] |
2. |
Wang, S., Wang, R., Liu, T., Lv, C., Liang, J., Kang, C., Zhou, L., Guo, J., Cui, G., Zhang, Y., Werck-Reichhart, D., Guo, L. and Huang, L. CYP76B74 catalyzes the 3′′-hydroxylation of geranylhydroquinone in shikonin biosynthesis. Plant Physiol. 179 (2019) 402–414. [PMID: 30498024] |
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[EC 1.14.14.174 created 2010 as EC 1.14.13.116, transferred 2020 to EC 1.14.14.174] |
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