EC |
1.1.1.389 |
Accepted name: |
2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase |
Reaction: |
2-dehydro-3-deoxy-L-galactonate + NAD+ = 3-deoxy-D-glycero-2,5-hexodiulosonate + NADH + H+ |
Systematic name: |
2-dehydro-3-deoxy-L-galactonate:NAD+ 5-oxidoreductase |
Comments: |
The enzyme, characterized from agarose-degrading bacteria, is involved in a degradation pathway for 3,6-anhydro-α-L-galactopyranose, a major component of the polysaccharides of red macroalgae. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Lee, S.B., Cho, S.J., Kim, J.A., Lee, S.Y., Kim, S.M. and Lim, H.S. Metabolic pathway of 3,6-anhydro-L-galactose in agar-degrading microorganisms. Biotechnol. Bioprocess Eng. 19 (2014) 866–878. |
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[EC 1.1.1.389 created 2015] |
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EC |
5.3.1.17 |
Accepted name: |
5-dehydro-4-deoxy-D-glucuronate isomerase |
Reaction: |
5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate |
Glossary: |
5-dehydro-4-deoxy-D-glucuronate = (4S,5R)-4,5-dihydroxy-2,6-dioxohexanoate
3-deoxy-D-glycero-2,5-hexodiulosonate = (4S)-4,6-dihydroxy-2,5-dioxohexanoate |
Other name(s): |
4-deoxy-L-threo-5-hexulose uronate isomerase; 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; kduI (gene name) |
Systematic name: |
5-dehydro-4-deoxy-D-glucuronate aldose-ketose-isomerase |
Comments: |
The enzyme is involved in the degradation of polygalacturonate, a later stage in the degradation of pectin by many microorganisms. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37318-44-8 |
References: |
1. |
Preiss, J. 4-Deoxy-L-threo-5-hexosulose uronic acid isomerase. Methods Enzymol. 9 (1966) 602–604. |
2. |
Condemine, G. and Robert-Baudouy, J. Analysis of an Erwinia chrysanthemi gene cluster involved in pectin degradation. Mol. Microbiol. 5 (1991) 2191–2202. [DOI] [PMID: 1766386] |
3. |
Dunten, P., Jaffe, H. and Aksamit, R.R. Crystallization of 5-keto-4-deoxyuronate isomerase from Escherichia coli. Acta Crystallogr. D Biol. Crystallogr. 54 (1998) 678–680. [PMID: 9761873] |
4. |
Crowther, R.L. and Georgiadis, M.M. The crystal structure of 5-keto-4-deoxyuronate isomerase from Escherichia coli. Proteins 61 (2005) 680–684. [DOI] [PMID: 16152643] |
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[EC 5.3.1.17 created 1972, modified 2012] |
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