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Your query returned 13 entries. Printable version
EC | 1.17.7.4 | ||||||||||||
Accepted name: | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase | ||||||||||||
Reaction: | (1) 3-methylbut-3-en-1-yl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ (2) prenyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ |
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For diagram of Non-Mevalonate terpenoid biosynthesis, click here | |||||||||||||
Glossary: | isopentenyl = 3-methylbut-3-en-1-yl prenyl = 3-methylbut-2-en-1-yl |
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Other name(s): | isopentenyl-diphosphate:NADP+ oxidoreductase; LytB; (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase; HMBPP reductase; IspH; LytB/IspH; isopentenyl-diphosphate:ferredoxin oxidoreductase | ||||||||||||
Systematic name: | 3-methylbut-3-en-1-yl-diphosphate:ferredoxin oxidoreductase | ||||||||||||
Comments: | An iron-sulfur protein that contains an unusual [4Fe-4S] cluster [5,6]. This enzyme forms a system with a ferredoxin or a flavodoxin and an NAD(P)H-dependent reductase. This is the last enzyme in the non-mevalonate pathway for isoprenoid biosynthesis. This pathway, also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP) or as the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found in most bacteria and in plant chloroplasts. The enzyme acts in the reverse direction, producing a 5:1 mixture of 3-methylbut-3-en-1-yl diphosphate and prenyl diphosphate. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 512789-14-9 | ||||||||||||
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EC | 2.5.1.1 | ||||||||||||
Accepted name: | dimethylallyltranstransferase | ||||||||||||
Reaction: | prenyl diphosphate + 3-methylbut-3-en-1-yl diphosphate = diphosphate + geranyl diphosphate | ||||||||||||
For diagram of terpenoid biosynthesis, click here | |||||||||||||
Glossary: | 3-methylbut-3-en-1-yl = isopentenyl (ambiguous) prenyl = 3-methylbut-2-en-1-yl = dimethylallyl (ambiguous) |
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Other name(s): | geranyl-diphosphate synthase; prenyltransferase; dimethylallyltransferase; DMAPP:IPP-dimethylallyltransferase; (2E,6E)-farnesyl diphosphate synthetase; diprenyltransferase; geranyl pyrophosphate synthase; geranyl pyrophosphate synthetase; trans-farnesyl pyrophosphate synthetase; dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase | ||||||||||||
Systematic name: | prenyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate prenyltranstransferase | ||||||||||||
Comments: | This enzyme will not accept larger prenyl diphosphates as efficient donors. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9032-79-5 | ||||||||||||
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EC | 2.5.1.69 | ||||||||||||
Accepted name: | lavandulyl diphosphate synthase | ||||||||||||
Reaction: | 2 prenyl diphosphate = diphosphate + lavandulyl diphosphate | ||||||||||||
For diagram of reaction, click here | |||||||||||||
Glossary: | lavandulyl = 5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl | ||||||||||||
Other name(s): | FDS-5; dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (lavandulyl-diphosphate-forming) | ||||||||||||
Systematic name: | prenyl-diphosphate:prenyl-diphosphate prenyltransferase (lavandulyl-diphosphate-forming) | ||||||||||||
Comments: | Lavandulyl diphosphate is a monoterpene with a non-head-to-tail linkage. It is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head-to-tail. When this enzyme is incubated with prenyl diphosphate and 3-methylbut-3-en-1-yl diphosphate, it also forms the regular monoterpene geranyl diphosphate [2]. The enzyme from Artemisia tridentata (big sagebrush) forms both lavandulyl diphosphate and chrysanthemyl diphosphate (see EC 2.5.1.67, chrysanthemyl diphosphate synthase) when prenyl diphosphate is the sole substrate. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
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EC | 2.5.1.71 | ||||||||||||
Accepted name: | leachianone-G 2′′-dimethylallyltransferase | ||||||||||||
Reaction: | prenyl diphosphate + leachianone G = diphosphate + sophoraflavanone G | ||||||||||||
For diagram of sophoraflavanone G biosynthesis, click here | |||||||||||||
Glossary: | dimethylallyl = prenyl = 3-methylbut-2-en-1-yl isopentenyl = 3-methylbut-3-en-1-yl lavandulyl = 5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl leachianone G = (–)-(2S)-2′-hydroxy-8-prenylnaringenin = (–)-(2S)-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-en-1-yl)-2,3-dihydro-4H-chromen-4-one sophoraflavanone G = (2S)-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-[(2R)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl]-2,3-dihydro-4H-chromen-4-one |
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Other name(s): | LG 2′′-dimethylallyltransferase; leachianone G 2′′-dimethylallyltransferase; LGDT; dimethylallyl-diphosphate:leachianone-G 2′′-dimethylallyltransferase | ||||||||||||
Systematic name: | prenyl-diphosphate:leachianone-G 2′′-prenyltransferase | ||||||||||||
Comments: | This membrane-bound enzyme is located in the plastids and requires Mg2+ for activity. The reaction forms the lavandulyl sidechain of sophoraflavanone G by transferring a prenyl group to the 2′′ position of another prenyl group attached at position 8 of leachianone G. The enzyme is specific for prenyl diphosphate as the prenyl donor, as it cannot be replaced by isopentenyl diphosphate or geranyl diphosphate. Euchrenone a7 (a 5-deoxy derivative of leachianone G) and kenusanone I (a 7-methoxy derivative of leachianone G) can also act as substrates, but more slowly. Along with EC 1.14.14.142 (8-dimethylallylnaringenin 2′-hydroxylase) and EC 2.5.1.70 (naringenin 8-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone-G-biosynthesis pathway. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||
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EC | 2.5.1.82 | ||||||||||||
Accepted name: | hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific] | ||||||||||||
Reaction: | geranylgeranyl diphosphate + 2 (3-methylbut-3-en-1-yl diphosphate) = 2 diphosphate + all-trans-hexaprenyl diphosphate | ||||||||||||
For diagram of terpenoid biosynthesis, click here | |||||||||||||
Other name(s): | HexPS(ambiguous); (all-E) hexaprenyl diphosphate synthase; (all-trans) hexaprenyl diphosphate synthase; hexaprenyl pyrophosphate synthase (ambiguous); HexPPs (ambiguous); hexaprenyl diphosphate synthase (ambiguous); geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units) | ||||||||||||
Systematic name: | geranylgeranyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate transferase (adding 2 units of 3-methylbut-3-en-1-yl) | ||||||||||||
Comments: | The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and prenyl diphosphate. Requires Mg2+ [1]. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
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EC | 2.5.1.83 | ||||||||||||
Accepted name: | hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] | ||||||||||||
Reaction: | (2E,6E)-farnesyl diphosphate + 3 (3-methylbut-3-en-1-yl diphosphate) = 3 diphosphate + all-trans-hexaprenyl diphosphate | ||||||||||||
For diagram of terpenoid biosynthesis, click here | |||||||||||||
Other name(s): | HexPS (ambiguous); hexaprenyl pyrophosphate synthetase (ambiguous); hexaprenyl diphosphate synthase (ambiguous); (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units) | ||||||||||||
Systematic name: | (2E,6E)-farnesyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate farnesyltranstransferase (adding 3 units of 3-methylbut-3-en-1-yl) | ||||||||||||
Comments: | The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and prenyl diphosphate [1]. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
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EC | 2.5.1.142 | ||||||||||||
Accepted name: | nerylneryl diphosphate synthase | ||||||||||||
Reaction: | prenyl diphosphate + 3 (3-methylbut-3-en-1-yl diphosphate) = 3 diphosphate + nerylneryl diphosphate (1a) prenyl diphosphate + 3-methylbut-3-en-1-yl diphosphate = diphosphate + neryl diphosphate (1b) neryl diphosphate + 3-methylbut-3-en-1-yl diphosphate = diphosphate + (2Z,6Z)-farnesyl diphosphate (1c) (2Z,6Z)-farnesyl diphosphate + 3-methylbut-3-en-1-yl diphosphate = diphosphate + nerylneryl diphosphate |
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For diagram of all-cis-polyprenyl diphosphate, click here | |||||||||||||
Glossary: | nerylneryl diphosphate = all-cis-tetraprenyl diphosphate | ||||||||||||
Other name(s): | CPT2; dimethylallyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 3 isopentenyl units) | ||||||||||||
Systematic name: | prenyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate cistransferase (adding 3 units of 3-methylbut-3-en-1-yl) | ||||||||||||
Comments: | Isolated from the plant Solanum lycopersicum (tomato). | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||
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EC | 2.5.1.158 | ||||||||||||
Accepted name: | hexaprenyl diphosphate synthase (prenyl-diphosphate specific) | ||||||||||||
Reaction: | prenyl diphosphate + 5 3-methylbut-3-en-1-yl diphosphate = all-trans-hexaprenyl diphosphate + 5 diphosphate | ||||||||||||
Glossary: | prenyl diphosphate = dimethylallyl diphosphate 3-methylbut-3-en-1-yl diphosphate = isopentenyl diphosphate |
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Other name(s): | HexPPS | ||||||||||||
Systematic name: | prenyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate transferase (adding 5 units of 3-methylbut-3-en-1-yl) | ||||||||||||
Comments: | This activity has been characterized from a number of fungal bifunctional enzymes. Following the formation of hexaprenyl diphosphate, a different domain in the enzymes catalyses its cyclization into a triterpene (see EC 4.2.3.221, macrophomene synthase and EC 4.2.3.220, talaropentaene synthase). cf. EC 2.5.1.82, hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
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EC | 2.7.4.26 | ||||||||||||
Accepted name: | isopentenyl phosphate kinase | ||||||||||||
Reaction: | ATP + 3-methylbut-3-en-1-yl phosphate = ADP + 3-methylbut-3-en-1-yl diphosphate | ||||||||||||
For diagram of the archaeal mevalonate pathway, click here | |||||||||||||
Other name(s): | ATP:isopentenyl phosphate phosphotransferase | ||||||||||||
Systematic name: | ATP:3-methylbut-3-en-1-yl-phosphate phosphotransferase | ||||||||||||
Comments: | The enzyme is involved in the mevalonate pathway in Archaea [1]. The activity has also been identified in the plant Mentha piperita (peppermint) [2]. It is strictly specific for ATP but can use other phosphate acceptors such as prenyl phosphate, geranyl phosphate, or fosfomycin. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
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EC | 3.6.1.76 | ||||||||||||
Accepted name: | prenyl-diphosphate phosphatase | ||||||||||||
Reaction: | (1) prenyl diphosphate + H2O = prenyl phosphate + phosphate (2) 3-methylbut-3-en-1-yl diphosphate + H2O = 3-methylbut-3-en-1-yl phosphate + phosphate |
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Glossary: | isopentenyl = 3-methylbut-3-en-1-yl prenyl = 3-methylbut-2-en-1-yl = dimethylallyl dimethylallyl diphosphate = DMAPP isopentenyl diphosphate = IPP |
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Systematic name: | prenyl diphosphate/3-methylbut-3-en-1-yl diphosphate phosphohydrolase | ||||||||||||
Comments: | The enzyme, characterized from the methanogenic archaeon Methanosarcina mazei, belongs to the Nudix hydrolase family (a superfamily of hydrolytic enzymes capable of cleaving nucleoside diphosphates linked to a moiety). Its main purpose is to provide the substrate for EC 2.5.1.129, flavin prenyltransferase. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||
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EC | 4.1.1.126 | ||||||||||||
Accepted name: | anhydromevalonate phosphate decarboxylase | ||||||||||||
Reaction: | trans-anhydromevalonate 5-phosphate = 3-methylbut-3-en-1-yl phosphate + CO2 | ||||||||||||
Glossary: | trans-anhydromevalonate 5-phosphate = (2E)-3-methyl-5-phosphooxypent-2-enoate 3-methylbut-3-en-1-yl phosphate = isopentenyl phosphate |
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Systematic name: | trans-anhydromevalonate 5-phosphate carboxy-lyase | ||||||||||||
Comments: | The enzyme catalyses a step in the archaeal prenyl diphosphate biosynthesis pathway. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||
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EC | 4.2.3.26 | ||||||||||||
Accepted name: | R-linalool synthase | ||||||||||||
Reaction: | geranyl diphosphate + H2O = (3R)-linalool + diphosphate | ||||||||||||
For diagram of acyclic monoterpenoid biosynthesis, click here | |||||||||||||
Glossary: | (3R)-linalool = (3R)-3,7-dimethylocta-1,6-dien-3-ol | ||||||||||||
Other name(s): | (3R)-linalool synthase; (–)-3R-linalool synthase | ||||||||||||
Systematic name: | geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming] | ||||||||||||
Comments: | Geranyl diphosphate cannot be replaced by isopentenyl diphosphate (3-methylbut-3-en-1-yl diphosphate), prenyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrate [1]. Requires Mg2+ or Mn2+ for activity. Unlike many other monoterpene synthases, only a single product, (3R)-linalool, is formed. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 254993-26-5 | ||||||||||||
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EC | 5.3.3.2 | ||||||||||||
Accepted name: | isopentenyl-diphosphate Δ-isomerase | ||||||||||||
Reaction: | 3-methylbut-3-en-1-yl diphosphate = prenyl diphosphate | ||||||||||||
For diagram of terpenoid biosynthesis, click here | |||||||||||||
Other name(s): | isopentenylpyrophosphate Δ-isomerase; methylbutenylpyrophosphate isomerase; isopentenylpyrophosphate isomerase; isopentenyl-diphosphate Δ3-Δ2-isomerase | ||||||||||||
Systematic name: | 3-methylbut-3-en-1-yl-diphosphate Δ3-Δ2-isomerase | ||||||||||||
Comments: | The enzyme from Streptomyces sp. strain CL190 requires FMN and NAD(P)H as cofactors. Activity is reduced if FMN is replaced by FAD, but the enzyme becomes inactive when NAD(P)H is replaced by NAD+ or NADP+. That enzyme also requires Mg2+, Mn2+ or Ca2+ for activity. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9033-27-6 | ||||||||||||
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