| EC |
1.1.1.57 |
| Accepted name: |
fructuronate reductase |
| Reaction: |
D-mannonate + NAD+ = D-fructuronate + NADH + H+ |
| Other name(s): |
mannonate oxidoreductase; mannonic dehydrogenase; D-mannonate dehydrogenase; D-mannonate:NAD oxidoreductase |
| Systematic name: |
D-mannonate:NAD+ 5-oxidoreductase |
| Comments: |
Also reduces D-tagaturonate. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9028-44-8 |
| References: |
| 1. |
Hickman, J. and Ashwell, G. Uronic acid metabolism in bacteria. II. Purification and properties of D-altronic acid and D-mannonic acid dehyrogenases in Escherichia coli. J. Biol. Chem. 235 (1960) 1566–1570. [PMID: 14401695] |
| 2. |
Kilgore, W.W. and Starr, M.P. Catabolism of galacturonic and glucuronic acids by Erwinia carotovora. J. Biol. Chem. 234 (1959) 2227–2235. [PMID: 14409051] |
|
| [EC 1.1.1.57 created 1965] |
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|
| EC |
1.1.1.380 |
| Accepted name: |
L-gulonate 5-dehydrogenase |
| Reaction: |
L-gulonate + NAD+ = D-fructuronate + NADH + H+ |
| Glossary: |
D-fructuronate = D-arabino-hexuronate |
| Systematic name: |
L-gulonate:NAD+ 5-oxidoreductase |
| Comments: |
The enzyme, characterized from the bacterium Halomonas elongata, participates in a pathway for L-gulonate degradation. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Cooper, R.A. The pathway for L-gulonate catabolism in Escherichia coli K-12 and Salmonella typhimurium LT-2. FEBS Lett. 115 (1980) 63–67. [DOI] [PMID: 6993236] |
| 2. |
Wichelecki, D.J., Vendiola, J.A., Jones, A.M., Al-Obaidi, N., Almo, S.C. and Gerlt, J.A. Investigating the physiological roles of low-efficiency D-mannonate and D-gluconate dehydratases in the enolase superfamily: pathways for the catabolism of L-gulonate and L-idonate. Biochemistry 53 (2014) 5692–5699. [DOI] [PMID: 25145794] |
|
| [EC 1.1.1.380 created 2014] |
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| EC |
5.1.2.7 |
| Accepted name: |
tagaturonate epimerase |
| Reaction: |
D-tagaturonate = D-fructuronate |
| Other name(s): |
fructuronate epimerase; tagaturonate/fructuronate epimerase; UxaE |
| Systematic name: |
D-tagaturonate 3-epimerase |
| Comments: |
The enzyme, present in bacteria, is involved in a degradation pathway of D-galacturonate. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Rodionova, I.A., Scott, D.A., Grishin, N.V., Osterman, A.L. and Rodionov, D.A. Tagaturonate-fructuronate epimerase UxaE, a novel enzyme in the hexuronate catabolic network in Thermotoga maritima. Environ. Microbiol. 14 (2012) 2920–2934. [DOI] [PMID: 22925190] |
|
| [EC 5.1.2.7 created 2017] |
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| EC |
5.3.1.12 |
| Accepted name: |
glucuronate isomerase |
| Reaction: |
D-glucuronate = D-fructuronate |
| Other name(s): |
uronic isomerase; uronate isomerase; D-glucuronate isomerase; uronic acid isomerase; D-glucuronate ketol-isomerase |
| Systematic name: |
D-glucuronate aldose-ketose-isomerase |
| Comments: |
Also converts D-galacturonate to D-tagaturonate. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9023-87-4 |
| References: |
| 1. |
Ashwell, G., Wahba, A.J. and Hickman, J. Uronic acid metabolism in bacteria. I. Purification and properties of uronic acid isomerase in Escherichia coli. J. Biol. Chem. 235 (1960) 1559–1565. [PMID: 13794771] |
| 2. |
Kilgore, W.W. and Starr, M.P. Catabolism of galacturonic and glucuronic acids by Erwinia carotovora. J. Biol. Chem. 234 (1959) 2227–2235. [PMID: 14409051] |
|
| [EC 5.3.1.12 created 1961] |
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