Accepted name: 3-keto-5-aminohexanoate cleavage enzyme
Reaction: (5S)-5-amino-3-oxohexanoate + acetyl-CoA = L-3-aminobutanoyl-CoA + acetoacetate
Glossary: L-3-aminobutyryl-CoA = (3S)-3-aminobutanoyl-CoA
Other name(s): kce (gene name)
Systematic name: (5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase
Comments: Requires Zn2+. The enzyme, isolated from the bacteria Fusobacterium nucleatum and Cloacimonas acidaminovorans, is involved in the anaerobic fermentation of lysine.
1.  Barker, H.A., Kahn, J.M. and Hedrick, L. Pathway of lysine degradation in Fusobacterium nucleatum. J. Bacteriol. 152 (1982) 201–207. [PMID: 6811551]
2.  Kreimeyer, A., Perret, A., Lechaplais, C., Vallenet, D., Medigue, C., Salanoubat, M. and Weissenbach, J. Identification of the last unknown genes in the fermentation pathway of lysine. J. Biol. Chem. 282 (2007) 7191–7197. [PMID: 17166837]
3.  Bellinzoni, M., Bastard, K., Perret, A., Zaparucha, A., Perchat, N., Vergne, C., Wagner, T., de Melo-Minardi, R.C., Artiguenave, F., Cohen, G.N., Weissenbach, J., Salanoubat, M. and Alzari, P.M. 3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation. J. Biol. Chem. 286 (2011) 27399–27405. [PMID: 21632536]
[EC created 2015]
Accepted name: 3-aminobutyryl-CoA ammonia-lyase
Reaction: L-3-aminobutyryl-CoA = crotonoyl-CoA + NH3
Other name(s): L-3-aminobutyryl-CoA deaminase; L-3-aminobutyryl-CoA ammonia-lyase
Systematic name: L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming)
Comments: Hydroxylamine can replace ammonia as a substrate. Crotonoyl-pantetheine can replace crotonoyl-CoA but it is a poorer substrate.
1.  Jeng, I.-M., Barker, H.A. Purification and properties of L-3-aminobutyryl coenzyme A deaminase from a lysine-fermenting Clostridium. J. Biol. Chem. 249 (1974) 6578–6584. [PMID: 4420467]
2.  Barker, H.A., Kahn, J.M., Chew, S. Enzymes involved in 3,5-diaminohexanoate degradation by Brevibacterium sp. J. Bacteriol. 143 (1980) 1165–1170. [PMID: 7410315]
[EC created 1999]