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Your query returned 3 entries. Printable version
EC | 2.1.1.254 | ||||
Accepted name: | erythromycin 3′′-O-methyltransferase | ||||
Reaction: | (1) S-adenosyl-L-methionine + erythromycin C = S-adenosyl-L-homocysteine + erythromycin A (2) S-adenosyl-L-methionine + erythromycin D = S-adenosyl-L-homocysteine + erythromycin B |
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For diagram of erythromycin biosynthesis, click here | |||||
Other name(s): | EryG | ||||
Systematic name: | S-adenosyl-L-methionine:erythromycin C 3′′-O-methyltransferase | ||||
Comments: | The enzyme methylates the 3 position of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A. It can also methylate the precursor erythromycin D, forming erythromycin B, which is then converted to erythromycin A by EC 1.14.13.154, erythromycin 12 hydroxylase. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 2.4.1.318 | ||||
Accepted name: | demethyllactenocin mycarosyltransferase | ||||
Reaction: | dTDP-β-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin | ||||
For diagram of tylosin biosynthesis, click here | |||||
Glossary: | dTDP-β-L-mycarose = dTDP-2,6-dideoxy-3-C-methyl-β-L-ribo-hexose demethyllactenocin = [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-D-allopyranoside |
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Other name(s): | tylCV (gene name); tylC5 (gene name) | ||||
Systematic name: | dTDP-β-L-mycarose:demethyllactenocin 4′-O-α-L-mycarosyltransferase | ||||
Comments: | The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 2.4.1.328 | ||||
Accepted name: | erythronolide mycarosyltransferase | ||||
Reaction: | dTDP-β-L-mycarose + erythronolide B = dTDP + 3-α-L-mycarosylerythronolide B | ||||
For diagram of erythromycin biosynthesis, click here | |||||
Glossary: | dTDP-β-L-mycarose = dTDP-2,6-dideoxy-3-C-methyl-β-L-ribo-hexose L-mycarose = 2,6-dideoxy-3-C-methyl-L-ribo-hexose |
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Other name(s): | EryBV | ||||
Systematic name: | dTDP-β-L-mycarose:erythronolide B L-mycarosyltransferase | ||||
Comments: | Isolated from the bacterium Saccharopolyspora erythraea. The enzyme is involved in the biosynthesis of the antibiotic erythromycin. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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