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Your query returned 5 entries. Printable version
EC | 1.14.99.50 | ||||||
Accepted name: | γ-glutamyl hercynylcysteine S-oxide synthase | ||||||
Reaction: | hercynine + γ-L-glutamyl-L-cysteine + O2 = γ-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O | ||||||
For diagram of ergothioneine and ovothiol biosynthesis, click here | |||||||
Glossary: | hercynine = Nα,Nα,Nα-trimethyl-L-histidine | ||||||
Other name(s): | EgtB | ||||||
Systematic name: | hercynine,γ-L-glutamyl-L-cysteine:oxygen oxidoreductase [γ-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide-forming] | ||||||
Comments: | Requires Fe2+ for activity. The enzyme, found in bacteria, is specific for both hercynine and γ-L-glutamyl-L-cysteine. It is part of the biosynthesis pathway of ergothioneine. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
References: |
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EC | 1.14.99.51 | ||||||
Transferred entry: | hercynylcysteine S-oxide synthase, now listed as EC 1.21.3.10, hercynylcysteine S-oxide synthase. | ||||||
EC | 1.21.3.10 | ||||||
Accepted name: | hercynylcysteine S-oxide synthase | ||||||
Reaction: | hercynine + L-cysteine + O2 = S-(hercyn-2-yl)-L-cysteine S-oxide + H2O | ||||||
For diagram of ergothioneine and ovothiol biosynthesis, click here | |||||||
Glossary: | hercynine = Nα,Nα,Nα-trimethyl-L-histidine | ||||||
Other name(s): | Egt1; Egt-1 | ||||||
Systematic name: | hercynine,L-cysteine:oxygen [S-(hercyn-2-yl)-L-cysteine S-oxide-forming] | ||||||
Comments: | Requires Fe2+ for activity. The enzyme, found in fungal species, is part of a fusion protein that also has the the activity of EC 2.1.1.44, L-histidine Nα-methyltransferase. It is part of the biosynthesis pathway of ergothioneine. The enzyme can also use L-selenocysteine to produce hercynylselenocysteine, which can be converted to selenoneine. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
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EC | 3.5.1.118 | ||||||
Accepted name: | γ-glutamyl hercynylcysteine S-oxide hydrolase | ||||||
Reaction: | γ-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O = S-(hercyn-2-yl)-L-cysteine S-oxide + L-glutamate | ||||||
For diagram of ergothioneine and ovothiol biosynthesis, click here | |||||||
Glossary: | hercynine = Nα,Nα,Nα-trimethyl-L-histidine = 3-(1H-imidazol-5-yl)-2-(trimethylamino)propanoate S-(hercyn-2-yl)-L-cysteine S-oxide = S-(N,N,N-trimethyl-L-histidin-2-yl)-L-cysteine S-oxide |
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Other name(s): | EgtC | ||||||
Systematic name: | γ-glutamyl-S-(hercyn-2-yl)cysteine S-oxide amidohydrolase | ||||||
Comments: | The enzyme is part of the biosynthesis pathway of ergothioneine in mycobacteria. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
References: |
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EC | 4.4.1.36 | ||||||
Accepted name: | hercynylcysteine S-oxide lyase | ||||||
Reaction: | S-(hercyn-2-yl)-L-cysteine S-oxide + reduced acceptor = ergothioneine + pyruvate + NH3 + acceptor (overall reaction) (1a) S-(hercyn-2-yl)-L-cysteine S-oxide + H2O = 2-(hydroxysulfanyl)hercynine + pyruvate + NH3 (1b) 2-(hydroxysulfanyl)hercynine + reduced acceptor = ergothioneine + acceptor + H2O (spontaneous) |
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Glossary: | 2-(hydroxysulfanyl)hercynine = Nα,Nα,Nα-trimethyl-2-(hydroxysulfanyl)-L-histidine = 2-sulfenohercynine ergothioneine = Nα,Nα,Nα-trimethyl-2-sulfanylidene-2,3-dihydro-L-histidine |
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Other name(s): | egtE (gene name) | ||||||
Systematic name: | S-(hercyn-2-yl)-L-cysteine ergothioneine-hydroxysulfanolate-lyase | ||||||
Comments: | Contains pyridoxal 5′-phosphate. The enzyme, characterized from the bacterium Mycobacterium smegmatis, cayalyses the last step in the pathway of ergothioneine biosynthesis. The enzyme forms a 2-(hydroxysulfanyl)hercynine intermediate, which is reduced to ergothioneine non-enzymically by a thiol. In vitro, DTT can serve this function. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
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