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Your query returned 5 entries. Printable version
EC | 1.1.1.349 | ||||
Accepted name: | norsolorinic acid ketoreductase | ||||
Reaction: | (1′S)-averantin + NADP+ = norsolorinic acid + NADPH + H+ | ||||
Glossary: | norsolorinic acid = 2-hexanoyl-1,3,6,8-tetrahydroxy-9,10-anthraquinone (1′S)-averantin = 1,3,6,8-tetrahydroxy-[(1S)-2-hydroxyhexyl]-9,10-anthraquinone |
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Other name(s): | aflD (gene name); nor-1 (gene name) | ||||
Systematic name: | (1′S)-averantin:NADP+ oxidoreductase | ||||
Comments: | Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 1.1.1.352 | ||||
Accepted name: | 5′-hydroxyaverantin dehydrogenase | ||||
Reaction: | (1) (1′S,5′S)-hydroxyaverantin + NAD+ = 5′-oxoaverantin + NADH + H+ (2) (1′S,5′R)-hydroxyaverantin + NAD+ = 5′-oxoaverantin + NADH + H+ |
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Glossary: | 5′-oxoaverantin = 1,3,6,8-tetrahydroxy-2-[(1S)-1-hydroxy-5-oxohexyl]anthracene-9,10-dione |
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Other name(s): | HAVN dehydrogenase; adhA (gene name) | ||||
Systematic name: | (1′S,5′S)-hydroxyaverantin:NAD+ oxidoreductase | ||||
Comments: | Isolated from the aflatoxin-producing mold Aspergillus parasiticus [2]. Involved in aflatoxin biosynthesis. 5′-Oxoaverantin will spontaneously form averufin by intramolecular ketalisation. cf. EC 4.2.1.142, 5′-oxoaverantin cyclase. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 1.14.13.174 | ||||
Transferred entry: | averantin hydroxylase. Now EC 1.14.14.116, averantin hydroxylase | ||||
EC | 1.14.14.116 | ||||
Accepted name: | averantin hydroxylase | ||||
Reaction: | (1) (1′S)-averantin + [reduced NADPH—hemoprotein reductase] + O2 = (1′S,5′S)-5′-hydroxyaverantin + [oxidized NADPH—hemoprotein reductase] + H2O (2) (1′S)-averantin + [reduced NADPH—hemoprotein reductase] + O2 = (1′S,5′R)-5′-hydroxyaverantin + [oxidized NADPH—hemoprotein reductase] + H2O |
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For diagram of aflatoxin biosynthesis (part 1), click here | |||||
Glossary: | averantin = 1,3,6,8-tetrahydroxy-2-[(1S)-1-hydroxyhexyl]anthracene-9,10-dione |
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Other name(s): | AVN hydroxylase; avnA (gene name); CYP60A1 | ||||
Systematic name: | (1′S)-averantin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (5′-hydroxylating) | ||||
Comments: | A cytochrome P-450 (heme-thiolate) protein isolated from the saprophytic mold Aspergillus parasiticus. Involved in aflatoxin biosynthesis. Does not react with (1′R)-averantin. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 4.2.1.142 | ||||
Accepted name: | 5′-oxoaverantin cyclase | ||||
Reaction: | 5′-oxoaverantin = (1′S,5′S)-averufin + H2O | ||||
For diagram of aflatoxin biosynthesis (part 1), click here | |||||
Glossary: | 5′-oxoaverantin = 1,3,6,8-tetrahydroxy-2-[(1S)-1-hydroxy-5-oxohexyl]anthracene-9,10-dione averufin = 7,9,11-trihydroxy-2-methyl-3,4,5,6-tetrahydro-2,6-epoxy-2H-anthra[2,3-b]oxocin-8,13-dione |
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Other name(s): | OAVN cyclase; 5′-oxoaverantin hydro-lyase [(2′S,5′S)-averufin forming] | ||||
Systematic name: | 5′-oxoaverantin hydro-lyase [(1′S,5′S)-averufin-forming] | ||||
Comments: | Isolated from the aflatoxin-producing mold Aspergillus parasiticus. The enzyme also catalyses the conversion of versiconal to versicolorin B (EC 4.2.1.143, versicolorin B synthase). Involved in aflatoxin biosynthesis. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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