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Your query returned 4 entries. Printable version
EC | 2.1.1.69 | ||||||||
Accepted name: | 5-hydroxyfuranocoumarin 5-O-methyltransferase | ||||||||
Reaction: | (1) S-adenosyl-L-methionine + a 5-hydroxyfurocoumarin = S-adenosyl-L-homocysteine + a 5-methoxyfurocoumarin (general reaction) (2) S-adenosyl-L-methionine + bergaptol = S-adenosyl-L-homocysteine + bergapten |
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For diagram of reaction, click here | |||||||||
Glossary: | bergaptol = 5-hydroxypsoralen O-methylbergaptol = bergapten = 5-methoxypsoralen |
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Other name(s): | furanocoumarin 5-methyltransferase; furanocoumarin 5-O-methyltransferase; bergaptol 5-O-methyltransferase; bergaptol O-methyltransferase; bergaptol methyltransferase; S-adenosyl-L-methionine:bergaptol O-methyltransferase; BMT; S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase | ||||||||
Systematic name: | S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase | ||||||||
Comments: | Converts bergaptol into bergapten, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities [4]. The enzyme methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin [3], but has little activity on non-coumarin phenols [1]. Caffeate, 5-hydroxyferulate and daphnetin are not substrates [4]. Cu2+, Zn2+ and Co2+ cause enzyme inhibition [4]. (see also EC 2.1.1.70, 8-hydroxyfuranocoumarin 8-O-methyltransferase) | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 67339-12-2, 101637-31-4 | ||||||||
References: |
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EC | 2.1.1.70 | ||||||||
Accepted name: | 8-hydroxyfuranocoumarin 8-O-methyltransferase | ||||||||
Reaction: | (1) S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin = S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin (general reaction) (2) S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin |
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For diagram of reaction, click here | |||||||||
Glossary: | xanthotoxin = O-methylxanthotoxol = 8-methoxypsoralen xanthotoxol = 8-hydroxypsoralen |
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Other name(s): | furanocoumarin 8-methyltransferase; furanocoumarin 8-O-methyl-transferase; xanthotoxol 8-O-methyltransferase; XMT; 8-hydroxyfuranocoumarin 8-O-methyltransferase; SAM:xanthotoxol O-methyltransferase; S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase; xanthotoxol methyltransferase; xanthotoxol O-methyltransferase; S-adenosyl-L-methionine:xanthotoxol O-methyltransferase; S-adenosyl-L-methionine-xanthotoxol O-methyltransferase | ||||||||
Systematic name: | S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase | ||||||||
Comments: | Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities [4]. Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols (see also EC 2.1.1.69, 5-hydroxyfuranocoumarin 5-O-methyltransferase). | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 67339-13-3 | ||||||||
References: |
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EC | 2.1.1.92 | ||||||||
Deleted entry: | bergaptol O-methyltransferase. Now included with EC 2.1.1.69, 5-hydroxyfuranocoumarin 5-O-methyltransferase. The reaction with bergaptol is a specific example of the general reaction associated with EC 2.1.1.69 | ||||||||
EC | 2.1.1.93 | ||||||||
Deleted entry: | xanthotoxol O-methyltransferase. Enzyme is identical to EC 2.1.1.70, 8-hydroxyfuranocoumarin 8-O-methyltransferase | ||||||||