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Your query returned 5 entries. Printable version
EC | 1.14.13.126 | ||||||||||||||
Transferred entry: | vitamin D3 24-hydroxylase. Now EC 1.14.15.16, vitamin D3 24-hydroxylase | ||||||||||||||
EC | 1.14.13.159 | ||||||||||||||
Transferred entry: | vitamin D 25-hydroxylase. Now EC 1.14.14.24, vitamin D 25-hydroxylase | ||||||||||||||
EC | 1.14.14.24 | ||||||||||||||
Accepted name: | vitamin D 25-hydroxylase | ||||||||||||||
Reaction: | calciol + O2 + [reduced NADPH—hemoprotein reductase] = calcidiol + [oxidized NADPH—hemoprotein reductase] + H2O | ||||||||||||||
For diagram of calciferol biosynthesis, click here | |||||||||||||||
Glossary: | calciol = cholecalciferol = vitamin D3 = (3S,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-3-ol calcidiol = 25-hydroxyvitamin D3 = (3S,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-3,25-diol |
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Other name(s): | vitamin D2 25-hydroxylase; vitamin D3 25-hydroxylase; CYP2R1 | ||||||||||||||
Systematic name: | calciol,NADPH—hemoprotein reductase:oxygen oxidoreductase (25-hydroxylating) | ||||||||||||||
Comments: | A microsomal enzyme isolated from human and mouse liver that bioactivates vitamin D3. While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) are able to catalyse the reaction in vitro, only CYP2R1 is thought to catalyse the reaction in humans in vivo [4]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH—hemoprotein reductase. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||
References: |
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EC | 1.14.15.16 | ||||||||||||||
Accepted name: | vitamin D3 24-hydroxylase | ||||||||||||||
Reaction: | (1) calcitriol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitetrol + 2 oxidized adrenodoxin + H2O (2) calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = secalciferol + 2 oxidized adrenodoxin + H2O |
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For diagram of calciferol biosynthesis, click here | |||||||||||||||
Glossary: | calcidiol = 25-hydroxyvitamin D3 = (3S,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-3,25-diol calcitriol = 1α,25-dihydroxyvitamin D3 = (1S,3R,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-1,3,25-triol calcitetrol = 1α,24R,25-trihydroxyvitamin D3 = (1S,3R,5Z,7E,24R)-9,10-seco-5,7,10(19)-cholestatriene-1,3,24,25-tetrol secalciferol = (24R)-24,25-dihydroxycalciol = 24R,25-dihydroxyvitamin D3 = (3R,5Z,7E,24R)-9,10-seco-5,7,10(19)-cholestatriene-3,24,25-triol |
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Other name(s): | CYP24A1 | ||||||||||||||
Systematic name: | calcitriol,adrenodoxin:oxygen oxidoreductase (24-hydroxylating) | ||||||||||||||
Comments: | This mitochondrial cytochrome P-450 enzyme requires adrenodoxin. The enzyme can perform up to 6 rounds of hydroxylation of the substrate calcitriol leading to calcitroic acid. The human enzyme also shows 23-hydroxylating activity leading to 1,25 dihydroxyvitamin D3-26,23-lactone as end product while the mouse and rat enzymes do not. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||
References: |
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EC | 1.14.15.22 | ||||||||||||||
Accepted name: | vitamin D 1,25-hydroxylase | ||||||||||||||
Reaction: | (1) calciol + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = calcidiol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O (2) calcidiol + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = calcitriol + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O |
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Glossary: | calciol = cholecalciferol = vitamin D3 = (3S,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-3-ol calcidiol = 25-hydroxyvitamin D3 = (3S,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-3,25-diol calcitriol = 1α,25-dihydroxyvitamin D3 = (1S,3R,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-1,3,25-triol |
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Other name(s): | CYP105A1; Streptomyces griseolus cytochrome P450SU-1 | ||||||||||||||
Systematic name: | calciol,ferredoxin:oxygen oxidoreductase (1,25-hydroxylating) | ||||||||||||||
Comments: | A P-450 (heme-thiolate) enzyme found in the bacterium Streptomyces griseolus. cf. EC 1.14.14.24, vitamin D 25-hydroxylase and EC 1.14.15.18, calcidiol 1-monooxygenase. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||
References: |
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