|
Your query returned 7 entries. Printable version
EC | 2.8.2.5 | ||||||||||||
Accepted name: | chondroitin 4-sulfotransferase | ||||||||||||
Reaction: | 3′-phosphoadenylyl sulfate + chondroitin = adenosine 3′,5′-bisphosphate + chondroitin 4′-sulfate | ||||||||||||
For diagram of chondroitin biosynthesis (later stages), click here | |||||||||||||
Glossary: | 3′-phosphoadenylyl sulfate = PAPS | ||||||||||||
Other name(s): | chondroitin sulfotransferase; 3′-phosphoadenylyl-sulfate:chondroitin 4′-sulfotransferase | ||||||||||||
Systematic name: | 3′-phosphoadenylyl-sulfate:chondroitin 4′-sulfonotransferase | ||||||||||||
Comments: | The sulfation takes place at the 4-position of N-acetyl-galactosamine residues of chondroitin. Not identical with EC 2.8.2.17 chondroitin 6-sulfotransferase. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 83589-04-2 | ||||||||||||
References: |
| ||||||||||||
EC | 2.8.2.33 | ||||||||||||
Accepted name: | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase | ||||||||||||
Reaction: | (1) 3′-phospho-5′-adenylyl sulfate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine = adenosine 3′,5′-bisphosphate + [dermatan]-4,6-di-O-sulfo-N-acetyl-D-galactosamine (2) 3′-phospho-5′-adenylyl sulfate + [chondroitin]-4-O-sulfo-N-acetyl-D-galactosamine = adenosine 3′,5′-bisphosphate + [chondroitin]-4,6-di-O-sulfo-N-acetyl-D-galactosamine |
||||||||||||
Other name(s): | GalNAc4S-6ST; CHST15 (gene name); 3′-phosphoadenylyl-sulfate:[dermatan]-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfotransferase | ||||||||||||
Systematic name: | 3′-phosphoadenylyl-sulfate:[dermatan]-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfonotransferase | ||||||||||||
Comments: | The enzyme is activated by divalent cations and reduced glutathione. The enzyme from human transfers sulfate to position 6 of both internal residues and non-reducing terminal GalNAc 4-sulfate residues of chondroitin sulfate and dermatan sulfate. Oligosaccharides derived from chondroitin sulfate also serve as acceptors but chondroitin sulfate E, keratan sulfate and heparan sulfate do not. Differs from EC 2.8.2.17, chondroitin 6-sulfotransferase, in being able to use both chondroitin and dermatan as effective substrates | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 242469-38-1 | ||||||||||||
References: |
| ||||||||||||
EC | 3.1.6.4 | ||||||||||||
Accepted name: | N-acetylgalactosamine-6-sulfatase | ||||||||||||
Reaction: | Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate | ||||||||||||
For diagram of the later stages of chondroitin biosynthesis, click here | |||||||||||||
Other name(s): | chondroitin sulfatase; chondroitinase; galactose-6-sulfate sulfatase; acetylgalactosamine 6-sulfatase; N-acetylgalactosamine-6-sulfate sulfatase; N-acetylgalactosamine 6-sulfatase | ||||||||||||
Systematic name: | N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9025-60-9 | ||||||||||||
References: |
| ||||||||||||
EC | 3.1.6.12 | ||||||||||||
Accepted name: | N-acetylgalactosamine-4-sulfatase | ||||||||||||
Reaction: | Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate | ||||||||||||
For diagram of the later stages of chondroitin biosynthesis, click here | |||||||||||||
Other name(s): | chondroitinsulfatase; chondroitinase; arylsulfatase B; acetylgalactosamine 4-sulfatase; N-acetylgalactosamine 4-sulfate sulfohydrolase | ||||||||||||
Systematic name: | N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase | ||||||||||||
Comments: | Acts also on N-acetylglucosamine 4-sulfate. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 55354-43-3 | ||||||||||||
References: |
| ||||||||||||
EC | 4.2.2.5 | ||||||||||||
Accepted name: | chondroitin AC lyase | ||||||||||||
Reaction: | Eliminative degradation of polysaccharides containing 1,4-β-D-hexosaminyl and 1,3-β-D-glucuronosyl linkages to disaccharides containing 4-deoxy-β-D-gluc-4-enuronosyl groups | ||||||||||||
Glossary: | chondroitin sulfate A = chondroitin 4-sulfate chondroitin sulfate C = chondroitin 6-sulfate For the nomenclature of glycoproteins, glycopeptides and peptidoglycans, click here |
||||||||||||
Other name(s): | chondroitinase (ambiguous); chondroitin sulfate lyase; chondroitin AC eliminase; chondroitinase AC; ChnAC | ||||||||||||
Systematic name: | chondroitin AC lyase | ||||||||||||
Comments: | Acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less well on hyaluronate. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(β1-3)GalNAc(β1-]n, which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(α1-3)GalNAc(β1-]n of DS. Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source [4]. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9047-57-8 | ||||||||||||
References: |
| ||||||||||||
EC | 4.2.2.20 | ||||||||||||
Accepted name: | chondroitin-sulfate-ABC endolyase | ||||||||||||
Reaction: | Endolytic cleavage of (1→4)-β-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Δ4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Δ4-unsaturated tetra- and disaccharides | ||||||||||||
For diagram of reaction click here | |||||||||||||
Glossary: | chondroitin sulfate A = chondroitin 4-sulfate chondroitin sulfate B = dermatan sulfate chondroitin sulfate C = chondroitin 6-sulfate For the nomenclature of glycoproteins, glycopeptides and peptidoglycans, click here |
||||||||||||
Other name(s): | chondroitinase (ambiguous); chondroitin ABC eliminase (ambiguous); chondroitinase ABC (ambiguous); chondroitin ABC lyase (ambiguous); chondroitin sulfate ABC lyase (ambiguous); ChS ABC lyase (ambiguous); chondroitin sulfate ABC endoeliminase; chondroitin sulfate ABC endolyase; ChS ABC lyase I | ||||||||||||
Systematic name: | chondroitin-sulfate-ABC endolyase | ||||||||||||
Comments: | This enzyme degrades a variety of glycosaminoglycans of the chondroitin-sulfate- and dermatan-sulfate type. Chondroitin sulfate, chondroitin-sulfate proteoglycan and dermatan sulfate are the best substrates but the enzyme can also act on hyaluronan at a much lower rate. Keratan sulfate, heparan sulfate and heparin are not substrates. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(β1-3)GalNAc(β1-]n, which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(α1-3)GalNAc(β1-]n of DS. Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source [5]. The related enzyme EC 4.2.2.21, chondroitin-sulfate-ABC exolyase, has the same substrate specificity but removes disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments produced by EC 4.2.2.20 [4]. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9024-13-9 | ||||||||||||
References: |
| ||||||||||||
EC | 4.2.2.21 | ||||||||||||
Accepted name: | chondroitin-sulfate-ABC exolyase | ||||||||||||
Reaction: | Exolytic removal of Δ4-unsaturated disaccharide residues from the non-reducing ends of both polymeric chondroitin/dermatan sulfates and their oligosaccharide fragments. | ||||||||||||
For diagram of reaction click here | |||||||||||||
Glossary: | chondroitin sulfate A = chondroitin 4-sulfate chondroitin sulfate B = dermatan sulfate chondroitin sulfate C = chondroitin 6-sulfate For the nomenclature of glycoproteins, glycopeptides and peptidoglycans, click here |
||||||||||||
Other name(s): | chondroitinase (ambiguous); chondroitin ABC eliminase (ambiguous); chondroitinase ABC (ambiguous); chondroitin ABC lyase (ambiguous); chondroitin sulfate ABC lyase (ambiguous); ChS ABC lyase (ambiguous); chondroitin sulfate ABC exoeliminase; chondroitin sulfate ABC exolyase; ChS ABC lyase II | ||||||||||||
Systematic name: | chondroitin-sulfate-ABC exolyase | ||||||||||||
Comments: | This enzyme degrades a variety of glycosaminoglycans of the chondroitin-sulfate- and dermatan-sulfate type. Chondroitin sulfate, chondroitin-sulfate proteoglycan and dermatan sulfate are the best substrates but the enzyme can also act on hyaluronan at a much lower rate. Keratan sulfate, heparan sulfate and heparin are not substrates. The related enzyme EC 4.2.2.20, chondroitin-sulfate-ABC endolyase, has the same substrate specificity but produces a mixture of oligosaccharides of different sizes that are ultimately degraded to tetra- and disaccharides [4]. Both enzymes act by the removal of a relatively acidic C-5 proton of the uronic acid followed by the elimination of a 4-linked hexosamine, resulting in the formation of an unsaturated C4—C5 bond on the hexuronic acid moiety of the products [4,6]. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 1000607-06-6 | ||||||||||||
References: |
| ||||||||||||