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Your query returned 10 entries. Printable version
EC | 2.1.1.144 | ||||||||
Accepted name: | trans-aconitate 2-methyltransferase | ||||||||
Reaction: | S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate | ||||||||
For diagram of reaction, click here | |||||||||
Glossary: | trans-aconitate = (E)-prop-1-ene-1,2,3-tricarboxylate | ||||||||
Systematic name: | S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2′-O-methyltransferase | ||||||||
Comments: | Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate as the product, that from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.145, trans-aconitate 3-methyltransferase). | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 235107-12-7 | ||||||||
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EC | 2.1.1.145 | ||||||||
Accepted name: | trans-aconitate 3-methyltransferase | ||||||||
Reaction: | S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate | ||||||||
For diagram of reaction, click here | |||||||||
Glossary: | trans-aconitate = (E)-prop-1-ene-1,2,3-tricarboxylate | ||||||||
Systematic name: | S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3′-O-methyltransferase | ||||||||
Comments: | Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate as the product, that from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.144, trans-aconitate 2-methyltransferase) | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 235107-12-7 | ||||||||
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EC | 4.1.1.6 | ||||||||
Accepted name: | cis-aconitate decarboxylase | ||||||||
Reaction: | cis-aconitate = itaconate + CO2 | ||||||||
Glossary: | itaconate = 2-methylenesuccinate cis-aconitate = (Z)-prop-1-ene-1,2,3-tricarboxylate |
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Other name(s): | cis-aconitic decarboxylase; cis-aconitate carboxy-lyase; CAD1 (gene name); IRG1 (gene name) | ||||||||
Systematic name: | cis-aconitate carboxy-lyase (itaconate-forming) | ||||||||
Comments: | The enzyme has been characterized from the fungus Aspergillus terreus and from human macrophages. cf. EC 4.1.1.113, trans-aconitate decarboxylase. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9025-01-8 | ||||||||
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EC | 4.1.1.113 | ||||||||
Accepted name: | trans-aconitate decarboxylase | ||||||||
Reaction: | trans-aconitate = itaconate + CO2 | ||||||||
Glossary: | trans-aconitate = (E)-prop-1-ene-1,2,3-tricarboxylate itaconate = 2-methylenesuccinate |
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Other name(s): | TAD1 (gene name) | ||||||||
Systematic name: | trans-aconitate carboxy-lyase (itaconate-forming) | ||||||||
Comments: | The enzyme, characterized from the smut fungus Ustilago maydis, is involved in an alternative pathway for the biosynthesis of itaconate. cf. EC 4.1.1.6, cis-aconitate decarboxylase. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
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EC | 4.2.1.3 | ||||||||
Accepted name: | aconitate hydratase | ||||||||
Reaction: | citrate = isocitrate (overall reaction) (1a) citrate = cis-aconitate + H2O (1b) cis-aconitate + H2O = isocitrate |
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For diagram of the citric acid cycle, click here and for diagram of the glyoxylate cycle, click here | |||||||||
Glossary: | isocitrate = (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate (previously known as threo-Ds-isocitrate) cis-aconitate = (Z)-prop-1-ene-1,2,3-tricarboxylate |
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Other name(s): | cis-aconitase; aconitase; AcnB; 2-methylaconitate hydratase; citrate(isocitrate) hydro-lyase | ||||||||
Systematic name: | citrate(isocitrate) hydro-lyase (cis-aconitate-forming) | ||||||||
Comments: | Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. An iron-sulfur protein, containing a [4Fe-4S] cluster to which the substrate binds. | ||||||||
Links to other databases: | BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9024-25-3 | ||||||||
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EC | 4.2.1.4 | ||||||||
Deleted entry: | citrate dehydratase. Now known to be a partial reaction catalysed by EC 4.2.1.3, aconitate hydratase. | ||||||||
EC | 4.2.1.79 | ||||||||
Accepted name: | 2-methylcitrate dehydratase | ||||||||
Reaction: | (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O | ||||||||
Glossary: | (2S,3S)-2-methylcitrate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate cis-2-methylaconitate = (Z)-but-2-ene-1,2,3-tricarboxylate |
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Other name(s): | 2-methylcitrate hydro-lyase; PrpD; 2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase | ||||||||
Systematic name: | (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming] | ||||||||
Comments: | The enzyme is specific for (2S,3S)-methylcitrate, showing no activity with (2R,3S)-methylcitrate [2]. The enzyme can also use cis-aconitate as a substrate but more slowly [2]. Both this enzyme and EC 4.2.1.3, aconitate hydratase, are required to complete the isomerization of (2S,3S)-methylcitrate to (2R,3S)-2-methylisocitrate [2]. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 80891-26-5 | ||||||||
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EC | 4.2.1.114 | ||||||||
Accepted name: | methanogen homoaconitase | ||||||||
Reaction: | (R)-2-hydroxybutane-1,2,4-tricarboxylate = (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate (overall reaction) (1a) (R)-2-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O (1b) (Z)-but-1-ene-1,2,4-tricarboxylate + H2O = (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate |
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For diagram of the 2-aminoadipate pathway of L-lysine synthesis, click here | |||||||||
Glossary: | cis-homoaconitate = (Z)-but-1-ene-1,2,4-tricarboxylate (R)-homocitrate = (R)-2-hydroxybutane-1,2,4-tricarboxylate homoisocitrate = (–)-threo-homoisocitrate = (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate |
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Other name(s): | methanogen HACN | ||||||||
Systematic name: | (R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming] | ||||||||
Comments: | This enzyme catalyses several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea. Requires a [4Fe-4S] cluster for activity. In contrast to EC 4.2.1.36, homoaconitate hydratase, this enzyme can catalyse both the dehydration of (R)-homocitrate to form cis-homoaconitate and the subsequent hydration reaction that forms homoisocitrate. In addition to cis-homoaconitate, the enzyme can also catalyse the hydration of the physiological substrates dihomoaconitate and trihomoaconitate as well as the non-physiological substrate tetrahomoaconitate. cis-Aconitate and threo-DL-isocitrate cannot act as substrates, and (S)-homocitrate and trans-homoaconitate act as inhibitors of the enzyme. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||
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EC | 4.2.1.117 | ||||||||
Accepted name: | 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming) | ||||||||
Reaction: | (2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H2O | ||||||||
Glossary: | (2S,3S)-2-methylcitrate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate 2-methyl-trans-aconitate = (2E)-but-2-ene-1,2,3-tricarboxylate |
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Systematic name: | (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase (2-methyl-trans-aconitate-forming) | ||||||||
Comments: | Catalyses the dehydration of (2S,3S)-2-methylcitrate, forming the trans isomer of 2-methyl-aconitate (unlike EC 4.2.1.79, which forms only the cis isomer). Part of a propionate degradation pathway. The enzyme from Shewanella oneidensis can also accept citrate and cis-aconitate, but activity with (2S,3S)-2-methylcitrate was approximately 2.5-fold higher. 2-methylisocitrate and isocitrate were not substrates [1]. An iron-sulfur protein. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
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EC | 5.3.3.7 | ||||||||
Accepted name: | aconitate Δ-isomerase | ||||||||
Reaction: | trans-aconitate = cis-aconitate | ||||||||
Glossary: | cis-aconitate = (Z)-prop-1-ene-1,2,3-tricarboxylate trans-aconitate = (E)-prop-1-ene-1,2,3-tricarboxylate |
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Other name(s): | aconitate isomerase | ||||||||
Systematic name: | aconitate Δ2-Δ3-isomerase | ||||||||
Comments: | cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. This isomerization could take place either in a direct cis-trans interconversion or by an allylic rearrangement; the enzyme has been shown to catalyse the latter change. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37318-48-2 | ||||||||
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