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Your query returned 5 entries. Printable version
EC | 2.4.99.20 | ||||||||||||||
Accepted name: | 2′-phospho-ADP-ribosyl cyclase/2′-phospho-cyclic-ADP-ribose transferase | ||||||||||||||
Reaction: | NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide (overall reaction) (1a) NADP+ = 2′-phospho-cyclic ADP-ribose + nicotinamide (1b) 2′-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate |
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For diagram of cyclic ADP-ribose biosynthesis, click here | |||||||||||||||
Glossary: | 2′-phospho-cyclic ADP-ribose = cADPRP nicotinic acid-adenine dinucleotide phosphate = NAADP+ |
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Other name(s): | diphosphopyridine nucleosidase (ambiguous); CD38 (gene name); BST1 (gene name) | ||||||||||||||
Systematic name: | NADP+:nicotinate ADP-ribosyltransferase | ||||||||||||||
Comments: | This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2′-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||
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EC | 3.2.2.5 | ||||||||||||||
Accepted name: | NAD+ glycohydrolase | ||||||||||||||
Reaction: | NAD+ + H2O = ADP-D-ribose + nicotinamide | ||||||||||||||
Glossary: | ADP-D-ribose = adenosine 5′-(5-deoxy-D-ribofuranos-5-yl diphosphate) | ||||||||||||||
Other name(s): | NAD glycohydrolase; nicotinamide adenine dinucleotide glycohydrolase; β-NAD+ glycohydrolase; DPNase (ambiguous); NAD hydrolase (ambiguous); diphosphopyridine nucleosidase (ambiguous); nicotinamide adenine dinucleotide nucleosidase (ambiguous); NAD nucleosidase (ambiguous); DPN hydrolase (ambiguous); NADase (ambiguous); nga (gene name); NAD+ nucleosidase | ||||||||||||||
Systematic name: | NAD+ glycohydrolase | ||||||||||||||
Comments: | This enzyme catalyses the hydrolysis of NAD+, without associated ADP-ribosyl cyclase activity (unlike the metazoan enzyme EC 3.2.2.6, bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase). The enzyme from Group A streptococci has been implicated in the pathogenesis of diseases such as streptococcal toxic shock-like syndrome (STSS) and necrotizing fasciitis. The enzyme from the venom of the snake Agkistrodon acutus also catalyses EC 3.6.1.5, apyrase [3]. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9025-46-1 | ||||||||||||||
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EC | 3.2.2.6 | ||||||||||||||
Accepted name: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | ||||||||||||||
Reaction: | NAD+ + H2O = ADP-D-ribose + nicotinamide (overall reaction) (1a) NAD+ = cyclic ADP-ribose + nicotinamide (1b) cyclic ADP-ribose + H2O = ADP-D-ribose |
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For diagram of cyclic ADP-ribose biosynthesis, click here | |||||||||||||||
Glossary: | ADP-D-ribose = adenosine 5′-(5-deoxy-D-ribofuranos-5-yl diphosphate) cyclic ADP-ribose = N1-(β-D-ribosyl)adenosine 5′(P1),5′′(P2)-cyclic diphosphate |
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Other name(s): | NAD+ nucleosidase; NADase (ambiguous); DPNase (ambiguous); DPN hydrolase (ambiguous); NAD hydrolase (ambiguous); nicotinamide adenine dinucleotide nucleosidase (ambiguous); NAD glycohydrolase (misleading); NAD nucleosidase (ambiguous); nicotinamide adenine dinucleotide glycohydrolase (misleading); CD38 (gene name); BST1 (gene name) | ||||||||||||||
Systematic name: | NAD+ glycohydrolase (cyclic ADP-ribose-forming) | ||||||||||||||
Comments: | This multiunctional enzyme acts on NAD+, catalysing both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 2.4.99.20, 2′-phospho-ADP-ribosyl cyclase/2′-phospho-cyclic-ADP-ribose transferase. It is also able to act on β-nicotinamide D-ribonucleotide. cf. EC 3.2.2.5, NAD+ glycohydrolase. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9032-65-9 | ||||||||||||||
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EC | 3.2.2.14 | ||||||||||||||
Accepted name: | NMN nucleosidase | ||||||||||||||
Reaction: | β-nicotinamide D-ribonucleotide + H2O = D-ribose 5-phosphate + nicotinamide | ||||||||||||||
Other name(s): | NMNase; nicotinamide mononucleotide nucleosidase; nicotinamide mononucleotidase; NMN glycohydrolase; NMNGhase | ||||||||||||||
Systematic name: | nicotinamide-nucleotide phosphoribohydrolase | ||||||||||||||
Comments: | The enzyme is thought to participate in an NAD+-salvage pathway. In eukaryotic organisms this activity has been attributed to EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37237-49-3 | ||||||||||||||
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EC | 3.6.1.53 | ||||||||||||||
Accepted name: | Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase | ||||||||||||||
Reaction: | (1) CDP-choline + H2O = CMP + phosphocholine (2) ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate |
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Other name(s): | Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase; ADPRibase-Mn | ||||||||||||||
Systematic name: | CDP-choline phosphohydrolase | ||||||||||||||
Comments: | Requires Mn2+. Unlike EC 3.6.1.13, ADP-ribose diphosphatase, it cannot utilize Mg2+. ADP-D-ribose, CDP-choline, CDP-ethanolamine and ADP are substrates for this enzyme but ADP-D-glucose, UDP-D-glucose, CDP-D-glucose, CDP, CMP and AMP are not hydrolysed [2]. The mammalian enzyme hydrolyses cyclic ADP-ribose to 1-(5-phospho-β-D-ribosyl)-AMP with ~100-fold lower efficiency than ADP-D-ribose [3]. In rat, the enzyme is found predominantly in thymus and spleen. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||
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