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Your query returned 2 entries. Printable version
EC | 1.3.3.13 | ||||
Accepted name: | albonoursin synthase | ||||
Reaction: | cyclo(L-leucyl-L-phenylalanyl) + 2 O2 = albonoursin + 2 H2O2 (overall reaction) (1a) cyclo(L-leucyl-L-phenylalanyl) + O2 = cyclo[(Z)-α,β-didehydrophenylalanyl-L-leucyl] + H2O2 (1b) cyclo[(Z)-α,β-didehydrophenylalanyl-L-leucyl] + O2 = albonoursin + H2O2 |
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For diagram of cyclic dipeptide biosynthesis, click here | |||||
Glossary: | cyclo(L-leucyl-L-phenylalanyl) = (3S,6S)-3-benzyl-6-(2-methylpropyl)piperazine-2,5-dione cyclo[(Z)-α,β-didehydrophenylalanyl-L-leucyl] = (3Z,6S)-3-benzylidene-6-(2-methylpropyl)piperazine-2,5-dione albonoursin = (3Z,6Z)-3-benzylidene-6-(2-methylpropylidene)piperazine-2,5-dione |
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Other name(s): | cyclo(dipeptide):oxygen oxidoreductase; cyclic dipeptide oxidase; AlbA | ||||
Systematic name: | cyclo(L-leucyl-L-phenylalanyl):oxygen oxidoreductase | ||||
Comments: | A flavoprotein from the bacterium Streptomyces noursei. The enzyme can also oxidize several other cyclo dipeptides, the best being cyclo(L-tryptophyl-L-tryptophyl) and cyclo(L-phenylalanyl-L-phenylalanyl) [1,2]. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 2.3.2.20 | ||||
Accepted name: | cyclo(L-leucyl-L-phenylalanyl) synthase | ||||
Reaction: | L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe = tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl) | ||||
For diagram of cyclic dipeptide biosynthesis, click here | |||||
Glossary: | cyclo(L-leucyl-L-phenylalanyl) = (3S,6S)-3-benzyl-6-(2-methylpropyl)piperazine-2,5-dione | ||||
Other name(s): | AlbC; cFL synthase | ||||
Systematic name: | L-leucyl-tRNALeu:L-phenylalanyl-tRNAPhe leucyltransferase (cyclizing) | ||||
Comments: | The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the L-phenylalanine residue [2]. The protein, found in the bacterium Streptomyces noursei, also forms cyclo(L-phenylalanyl-L-phenylalanyl), cyclo(L-methionyl-L-phenylalanyl), cyclo(L-phenylalanyl-L-tyrosyl) and cyclo(L-methionyl-L-tyrosyl) [1]. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
References: |
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