The Enzyme Database

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EC 2.7.7.54      
Deleted entry: phenylalanine adenylyltransferase. The activity is part of EC 6.3.2.40, cyclopeptine synthase.
[EC 2.7.7.54 created 1989, deleted 2013]
 
 
EC 2.7.7.55      
Deleted entry: anthranilate adenylyltransferase. The activity is part of EC 6.3.2.40, cyclopeptine synthase.
[EC 2.7.7.55 created 1989, deleted 2013]
 
 
EC 6.3.2.40     
Accepted name: cyclopeptine synthase
Reaction: 2 ATP + S-adenosyl-L-methionine + anthranilate + L-phenylalanine = cyclopeptine + 2 AMP + 2 diphosphate + S-adenosyl-L-homocysteine
For diagram of reaction, click here
Glossary: cyclopeptine = (3S)-3-benzyl-4-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione
Systematic name: S-adenosyl-L-methionine:anthranilate:L-phenylalanine ligase (cyclopeptine-forming)
Comments: Cyclopeptine synthase is the key enzyme of benzodiazepine alkaloid biosynthesis in the fungus Penicillium cyclopium. The enzyme is a non-ribosomal peptide synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Lerbs, W. and Luckner, M. Cyclopeptine synthetase activity in surface cultures of Penicillium cyclopium. J. Basic Microbiol. 25 (1985) 387–391. [DOI] [PMID: 2995633]
2.  Gerlach, M, Schwelle, N., Lerbs, W. and Luckner, M. Enzymatic synthesis of cyclopeptine intermediates in Penicillium cyclopium. Phytochemistry 24 (1985) 1935–1939.
[EC 6.3.2.40 created 2013]
 
 


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