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Your query returned 3 entries. Printable version
EC | 1.3.1.72 | ||||||||||
Accepted name: | Δ24-sterol reductase | ||||||||||
Reaction: | 5α-cholest-7-en-3β-ol + NADP+ = 5α-cholesta-7,24-dien-3β-ol + NADPH + H+ | ||||||||||
For diagram of sterol-sidechain modification, click here | |||||||||||
Glossary: | desmosterol = cholesta-5,24-dien-3β-ol lanosterol = 4,4,14-trimethyl-5α-cholesta-8,24-dien-3β-ol zymostrol = 5α-cholesta-8,24-dien-3β-ol |
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Other name(s): | lanosterol Δ24-reductase | ||||||||||
Systematic name: | sterol:NADP+ Δ24-oxidoreductase | ||||||||||
Comments: | Acts on a range of steroids with a 24(25)-double bond, including lanosterol, desmosterol and zymosterol. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9033-57-2 | ||||||||||
References: |
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EC | 2.1.1.41 | ||||||||||
Accepted name: | sterol 24-C-methyltransferase | ||||||||||
Reaction: | S-adenosyl-L-methionine + 5α-cholesta-8,24-dien-3β-ol = S-adenosyl-L-homocysteine + 24-methylene-5α-cholest-8-en-3β-ol | ||||||||||
For diagram of sterol sidechain modification, click here | |||||||||||
Glossary: | desmosterol = cholesta-5,24-dien-3β-ol zymostrol = 5α-cholesta-8,24-dien-3β-ol |
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Other name(s): | Δ24-methyltransferase; Δ24-sterol methyltransferase; zymosterol-24-methyltransferase; S-adenosyl-4-methionine:sterol Δ24-methyltransferase; SMT1; 24-sterol C-methyltransferase; S-adenosyl-L-methionine:Δ24(23)-sterol methyltransferase; phytosterol methyltransferase | ||||||||||
Systematic name: | S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase | ||||||||||
Comments: | Requires glutathione. Acts on a range of sterols with a 24(25)-double bond in the sidechain. While zymosterol is the preferred substrate it also acts on desmosterol, 5α-cholesta-7,24-dien-3β-ol, 5α-cholesta-5,7,24-trien-3β-ol, 4α-methylzymosterol and others. S-Adenosyl-L-methionine attacks the Si-face of the 24(25) double bond and the C-24 hydrogen is transferred to C-25 on the Re face of the double bond. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37257-07-1 | ||||||||||
References: |
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EC | 4.1.2.33 | ||||||||||
Accepted name: | fucosterol-epoxide lyase | ||||||||||
Reaction: | (24R,241R)-fucosterol epoxide = desmosterol + acetaldehyde | ||||||||||
Glossary: | (24R,241R)-fucosterol epoxide = (3β,24R,28R)-24,28-epoxystigmast-5-en-3-ol | ||||||||||
Other name(s): | (24R,24′R)-fucosterol-epoxide acetaldehyde-lyase; (24R,24′R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming) | ||||||||||
Systematic name: | (24R,241R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming) | ||||||||||
Comments: | The insect enzyme is involved in the conversion of sitosterol into cholesterol. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 99676-42-3 | ||||||||||
References: |
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