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Your query returned 7 entries. 
Printable version
| EC | 1.14.99.50 | ||||||||
| Accepted name: | γ-glutamyl hercynylcysteine S-oxide synthase | ||||||||
| Reaction: | hercynine + γ-L-glutamyl-L-cysteine + O2 = γ-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O | ||||||||
| For diagram of ergothioneine and ovothiol biosynthesis, click here | |||||||||
| Glossary: | hercynine = Nα,Nα,Nα-trimethyl-L-histidine | ||||||||
| Other name(s): | EgtB | ||||||||
| Systematic name: | hercynine,γ-L-glutamyl-L-cysteine:oxygen oxidoreductase [γ-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide-forming] | ||||||||
| Comments: | Requires Fe2+ for activity. The enzyme, found in bacteria, is specific for both hercynine and γ-L-glutamyl-L-cysteine. It is part of the biosynthesis pathway of ergothioneine. | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||
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| EC | 1.14.99.51 | ||||||||
| Transferred entry: | hercynylcysteine S-oxide synthase, now listed as EC 1.21.3.10, hercynylcysteine S-oxide synthase. | ||||||||
| EC | 1.14.99.52 | ||||||||
| Accepted name: | L-cysteinyl-L-histidinylsulfoxide synthase | ||||||||
| Reaction: | L-histidine + L-cysteine + O2 = S-(L-histidin-5-yl)-L-cysteine S-oxide + H2O | ||||||||
| For diagram of ergothioneine and ovothiol biosynthesis, click here | |||||||||
| Glossary: | S-(L-histidin-5-yl)-L-cysteine S-oxide = 5-{[(2R)-2-amino-2-carboxyethyl]sulfinyl}-L-histidine | ||||||||
| Other name(s): | OvoA | ||||||||
| Systematic name: | L-histidine,L-cysteine:oxygen [S-(L-histidin-5-yl)-L-cysteine S-oxide-forming] | ||||||||
| Comments: | Requires Fe2+ for activity. The enzyme participates in ovothiol biosynthesis. It also has some activity as EC 1.13.11.20, cysteine dioxygenase, and can perform the reaction of EC 1.14.99.50, γ-glutamyl hercynylcysteine sulfoxide synthase, albeit with low activity [4]. | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
| References: |
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| EC | 1.21.3.10 | ||||||||
| Accepted name: | hercynylcysteine S-oxide synthase | ||||||||
| Reaction: | hercynine + L-cysteine + O2 = S-(hercyn-2-yl)-L-cysteine S-oxide + H2O | ||||||||
| For diagram of ergothioneine and ovothiol biosynthesis, click here | |||||||||
| Glossary: | hercynine = Nα,Nα,Nα-trimethyl-L-histidine | ||||||||
| Other name(s): | Egt1; Egt-1 | ||||||||
| Systematic name: | hercynine,L-cysteine:oxygen [S-(hercyn-2-yl)-L-cysteine S-oxide-forming] | ||||||||
| Comments: | Requires Fe2+ for activity. The enzyme, found in fungal species, is part of a fusion protein that also has the the activity of EC 2.1.1.44, L-histidine Nα-methyltransferase. It is part of the biosynthesis pathway of ergothioneine. The enzyme can also use L-selenocysteine to produce hercynylselenocysteine, which can be converted to selenoneine. | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
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| EC | 2.1.1.44 | ||||||||
| Accepted name: | L-histidine Nα-methyltransferase | ||||||||
| Reaction: | 3 S-adenosyl-L-methionine + L-histidine = 3 S-adenosyl-L-homocysteine + hercynine (overall reaction) (1a) S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + Nα-methyl-L-histidine (1b) S-adenosyl-L-methionine + Nα-methyl-L-histidine = S-adenosyl-L-homocysteine + Nα,Nα-dimethyl-L-histidine (1c) S-adenosyl-L-methionine + Nα,Nα-dimethyl-L-histidine = S-adenosyl-L-homocysteine + hercynine |
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| For diagram of ergothioneine and ovothiol biosynthesis, click here | |||||||||
| Glossary: | hercynine = Nα,Nα,Nα-trimethyl-L-histidine | ||||||||
| Other name(s): | dimethylhistidine N-methyltransferase; dimethylhistidine methyltransferase; histidine-α-N-methyltransferase; S-adenosyl-L-methionine:α-N,α-N-dimethyl-L-histidine α-N-methyltransferase; S-adenosyl-L-methionine:Nα,Nα-dimethyl-L-histidine Nα-methyltransferase | ||||||||
| Systematic name: | S-adenosyl-L-methionine:L-histidine Nα-methyltransferase (hercynine-forming) | ||||||||
| Comments: | Part of the biosynthetic pathway of ergothioneine. | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 62213-53-0 | ||||||||
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| EC | 3.5.1.118 | ||||||||
| Accepted name: | γ-glutamyl hercynylcysteine S-oxide hydrolase | ||||||||
| Reaction: | γ-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O = S-(hercyn-2-yl)-L-cysteine S-oxide + L-glutamate | ||||||||
| For diagram of ergothioneine and ovothiol biosynthesis, click here | |||||||||
| Glossary: | hercynine = Nα,Nα,Nα-trimethyl-L-histidine = 3-(1H-imidazol-5-yl)-2-(trimethylamino)propanoate S-(hercyn-2-yl)-L-cysteine S-oxide = S-(N,N,N-trimethyl-L-histidin-2-yl)-L-cysteine S-oxide |
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| Other name(s): | EgtC | ||||||||
| Systematic name: | γ-glutamyl-S-(hercyn-2-yl)cysteine S-oxide amidohydrolase | ||||||||
| Comments: | The enzyme is part of the biosynthesis pathway of ergothioneine in mycobacteria. | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||
| References: |
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| EC | 4.4.1.36 | ||||||||
| Accepted name: | hercynylcysteine S-oxide lyase | ||||||||
| Reaction: | S-(hercyn-2-yl)-L-cysteine S-oxide + reduced acceptor = ergothioneine + pyruvate + NH3 + acceptor (overall reaction) (1a) S-(hercyn-2-yl)-L-cysteine S-oxide + H2O = 2-(hydroxysulfanyl)hercynine + pyruvate + NH3 (1b) 2-(hydroxysulfanyl)hercynine + reduced acceptor = ergothioneine + acceptor + H2O (spontaneous) |
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| Glossary: | 2-(hydroxysulfanyl)hercynine = Nα,Nα,Nα-trimethyl-2-(hydroxysulfanyl)-L-histidine = 2-sulfenohercynine ergothioneine = Nα,Nα,Nα-trimethyl-2-sulfanylidene-2,3-dihydro-L-histidine |
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| Other name(s): | egtE (gene name) | ||||||||
| Systematic name: | S-(hercyn-2-yl)-L-cysteine ergothioneine-hydroxysulfanolate-lyase | ||||||||
| Comments: | Contains pyridoxal 5′-phosphate. The enzyme, characterized from the bacterium Mycobacterium smegmatis, cayalyses the last step in the pathway of ergothioneine biosynthesis. The enzyme forms a 2-(hydroxysulfanyl)hercynine intermediate, which is reduced to ergothioneine non-enzymically by a thiol. In vitro, DTT can serve this function. | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
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