The Enzyme Database

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EC 1.14.11.60     
Accepted name: scopoletin 8-hydroxylase
Reaction: scopoletin + 2-oxoglutarate + O2 = fraxetin + succinate + CO2
Glossary: fraxetin = 7,8-dihydroxy-6-methoxy-2H-chromen-2-one
scopoletin = 7-hydroxy-6-methoxy-2H-chromen-2-one
Other name(s): S8H (gene name)
Systematic name: scopoletin,2-oxoglutarate:oxygen oxidoreductase (8-hydroxylating)
Comments: Requires iron(II) and ascorbate. A protein involved in biosynthesis of iron(III)-chelating coumarins in higher plants.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Siwinska, J., Siatkowska, K., Olry, A., Grosjean, J., Hehn, A., Bourgaud, F., Meharg, A.A., Carey, M., Lojkowska, E. and Ihnatowicz, A. Scopoletin 8-hydroxylase: a novel enzyme involved in coumarin biosynthesis and iron-deficiency responses in Arabidopsis. J. Exp. Bot. 69 (2018) 1735–1748. [PMID: 29361149]
2.  Rajniak, J., Giehl, R.FH., Chang, E., Murgia, I., von Wiren, N. and Sattely, E.S. Biosynthesis of redox-active metabolites in response to iron deficiency in plants. Nat. Chem. Biol. 14 (2018) 442–450. [PMID: 29581584]
[EC 1.14.11.60 created 2018]
 
 
EC 1.14.14.164     
Accepted name: fraxetin 5-hydroxylase
Reaction: fraxetin + [reduced NADPH—hemoprotein reductase] + O2 = sideretin (reduced form) + [oxidized NADPH—hemoprotein reductase] + H2O
Glossary: fraxetin = 7,8-dihydroxy-6-methoxy-2H-chromen-2-one
sideretin (reduced form) = 5,7,8-trihydroxy-6-methoxy-2H-chromen-2-one
Other name(s): CYP82C4; fraxetin 5-monooxygenase
Systematic name: fraxetin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (5-hydroxylating)
Comments: A cytochrome P-450 (heme-thiolate) protein involved in biosynthesis of iron(III)-chelating coumarins in higher plants.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Rajniak, J., Giehl, R.FH., Chang, E., Murgia, I., von Wiren, N. and Sattely, E.S. Biosynthesis of redox-active metabolites in response to iron deficiency in plants. Nat. Chem. Biol. 14 (2018) 442–450. [PMID: 29581584]
[EC 1.14.14.164 created 2018]
 
 


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