The Enzyme Database

Your query returned 4 entries.    printer_iconPrintable version

Accepted name: licodione 2′-O-methyltransferase
Reaction: S-adenosyl-L-methionine + licodione = S-adenosyl-L-homocysteine + 2′-O-methyllicodione
For diagram of licodione biosynthesis, click here
Systematic name: S-adenosyl-L-methionine:licodione 2′-O-methyltransferase
Comments: As well as licodione [1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1,3-propanedione], the 2′′-hydroxy-derivative and isoliquiritigenin can act as acceptors, but more slowly.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 77000-07-8
1.  Ayabe, S.-I., Yoshikawa, T., Kobayashi, M. and Furuya, T. Biosynthesis of retrochalcone, echinatin: involvement of O-methyltransferase to licodione. Phytochemistry 19 (1980) 2331–2336.
[EC created 1983]
Accepted name: isoliquiritigenin 2′-O-methyltransferase
Reaction: S-adenosyl-L-methionine + isoliquiritigenin = S-adenosyl-L-homocysteine + 2′-O-methylisoliquiritigenin
For diagram of daidzein biosynthesis, click here
Glossary: isoliquiritigenin = 4,2′,4′-trihydroxychalcone
Other name(s): chalcone OMT; CHMT
Systematic name: S-adenosyl-L-methionine:isoliquiritigenin 2′-O-methyltransferase
Comments: Not identical to EC, licodione 2′-O-methyltransferase [2]. While EC, isoliquiritigenin 2′-O-methyltransferase can use licodione as a substrate, EC cannot use isoliquiritigenin as a substrate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 139317-14-9
1.  Maxwell, C.A., Edwards, R. and Dixon, R.A. Identification, purification, and characterization of S-adenosyl-L-methionine: isoliquiritigenin 2′-O-methyltransferase from alfalfa (Medicago sativa L.). Arch. Biochem. Biophys. 293 (1992) 158–166. [DOI] [PMID: 1731632]
2.  Ichimura, M., Furuno, T., Takahashi, T., Dixon, R.A. and Ayabe, S. Enzymic O-methylation of isoliquiritigenin and licodione in alfalfa and licorice cultures. Phytochemistry 44 (1997) 991–995. [DOI] [PMID: 9055445]
[EC created 2004]
Accepted name: xanthohumol 4-O-methyltransferase
Reaction: S-adenosyl-L-methionine + xanthohumol = S-adenosyl-L-homocysteine + 4-O-methylxanthohumol
For diagram of xanthohumol biosynthesis, click here
Glossary: xanthohumol = 2′,4,4′-trihydroxy-6′-methoxy-3-prenylchalcone = (2E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
4-O-methylxanthohumol =2′,4′-dihydroxy-4,6′-dimethoxy-3-prenylchalcone = (2E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-methoxyphenyl)prop-2-en-1-one
Other name(s): OMT2 (ambiguous); S-adenosyl-L-methionine:xanthohumol 4′-O-methyltransferase (incorrect); xanthohumol 4′-O-methyltransferase (incorrect)
Systematic name: S-adenosyl-L-methionine:xanthohumol 4-O-methyltransferase
Comments: The enzyme from hops (Humulus lupulus) has a broad substrate specificity. The best substrates in vitro are resveratrol, desmethylxanthohumol, naringenin chalcone and isoliquiritigenin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Nagel, J., Culley, L.K., Lu, Y., Liu, E., Matthews, P.D., Stevens, J.F. and Page, J.E. EST analysis of hop glandular trichomes identifies an O-methyltransferase that catalyzes the biosynthesis of xanthohumol. Plant Cell 20 (2008) 186–200. [DOI] [PMID: 18223037]
[EC created 2017, modified 2018]
Accepted name: 6′-deoxychalcone synthase
Reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O
For diagram of daidzein biosynthesis, click here
Glossary: isoliquiritigenin = 4,2′,4′-trihydroxychalcone
liquiritigenin = 7,4′-dihydroxyflavanone
Systematic name: malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing)
Comments: Isoliquiritigenin is the precursor of liquiritigenin, a 5-deoxyflavanone.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 114308-23-5
1.  Ayabe, S., Udagawa, A. and Furuya, T. NAD(P)H-dependent 6′-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract. Arch. Biochem. Biophys. 261 (1988) 458–462. [DOI] [PMID: 3355160]
[EC created 2004]

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